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Global T-cell Therapy Market by Therapy (Tumor-Infiltrating Lymphocytes, CAR T-cell), by Indication (Hematologic Malignancies, Solid Tumors) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

  • Report ID: PH-73159
  • Author: Up Market Research
  • Rating: 4.7
  • Total Reviews: 66
  • No. Of Pages: 204
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  • Pub. Date: 2021-10-21
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Summary of the Report

Global T-cell therapy market was valued at USD4.6 billion in 2020. It is expected to grow at a compound annual rate (CAGR of 20.2%) between 2021 and 2028. Many companies have changed their business models, shifting from developing small molecule- and protein-based therapies to adoptive therapies, following approvals by Yescarta and Kymriah. This has fueled strategic investments by both the private and public agencies in this area, which has pushed the market for T cell therapy.

In the next few years, T-cell therapy companies will face increased competition due to increasing approvals and expanding manufacturing capabilities. Kite Pharma's Tecartus, the only CAR–T therapeutic product for mantle-cell lymphoma, received a marketing authorization from the European Medicine Agency in December 2020.

The global COVID-19 epidemic has also prompted investment in the deciphering of the use of T-cell therapies for viral infection research. In December 2020, a study showed the potential for this therapy to be used to treat COVID-19 high-risk patients. In September 2020, the U.S. FDA approved the IND application for ALVR109 in order to treat COVID-19 sufferers. This will likely increase the use of T-cell therapies for viral infections.

The majority of cancer immunotherapy currently uses a T-cell-based method due to its higher success rate. More than 350 clinical trials for CAR-T have been registered in China as of June 2020. These numbers show the increasing importance of Chimeric Antigen Receptor Therapy in cancer treatment. To improve their market position in the near future, most operating players are now investing in CD19-CAR-T therapies.

CAR-T therapies are thriving because of the growing gene therapy market. This space will continue to grow with increasing investment in gene therapy. Novartis AG and other companies are actively exploring the potential for CAR-T-based gene therapy for multiple chronic indications.

COVID-19 Impact: The market's revenue is boosted by the success of Kymriah & Yescarta

Pandemic Impact

Outlook after COVID

The commercial market segment is driven by the July 2020 approval of Tecartus for mantle cell lymphoma treatment.

A number of major players have begun to adopt digital alternatives to manage cell therapy supply chains due to the current uncertainty in the supply chain as a result of the COVID-19 pandemic. This trend is expected to continue into the future.

CAR-T cells therapy are the main driving segment. In 2020, there was a 37% increase in year-over-year growth due to Kymriah and Yescarta as well as other piepilne program candidates.

TrakCel would see an increase in strategic alliances between therapy developers and supply chain solution providers to help accelerate and achieve supply chains harmonization within closed-system manufacturing.

Modality Insights

Due to the large number of products currently in clinical development, the research segment was the dominant market for T-cell treatment. It accounted for over 75.0% revenue share in 2020. CAR-T therapy is a preferred method for cancer management and a large number of research institutions such as Mayo Clinic have been involved in its development.

Many operating entities collaborate with researchers around the world, which has led to a shift in focus to accelerate the development of CAR–T therapies and expand the therapeutic applications landscape. In October 2020, Immuneel Therapeutics partnered with Institut d'Investigacions Biomediques August Pi i Sunyer et Hospital Clinic de Barcelona to develop and commercialize CAR-T therapy for India.

Regulators are focusing their efforts to promote the commercial use these therapies in hospital and clinical settings. The Centers for Medicare and Medicaid Service (CMS), in August 2020, established policies for reimbursement and coverage for CAR-T cells therapy. The policy raised the amount of payment to 65% of total cost. This would encourage commercial revenue growth.

Therapy Type Insights

CAR T cell therapy was the dominant market segment for T-cell therapy in 2020. It accounted for the largest revenue share at 82.0%. This is due to an exponential increase in CAR-T therapies clinical trials and increasing involvement by key players. There are many new players and academic institutions that conduct clinical trials for CAR–T therapeutic products for different indications. This supports the market's dominance.

CAR-T therapy manufacturing has made it easier to increase the use of these therapies for various types of cancer. New approaches, such as the second-generation, next generation CAR-T immunotherapy, may be able to overcome resistance and side effects, thereby increasing organic revenue generation.

Because of their potential to treat solid tumors, T-cell receptor-based treatments ranked second in the global space. This market is becoming increasingly popular for the treatment of melanomas. Adaptimmune, in partnership with GlaxoSmithKline, focuses on TCR treatment for melanoma.

Indication Insights

The market for T-cell therapy was dominated by the segment of hematologic malignancies in 2020. It accounted for 49.0% of the revenue share. CAR-T cell therapies are primarily used to treat hematological cancers such as lymphoma and leukemia. The segment will see high competition due to the large number of market players and the high fixed costs associated with autologous cell production.

CAR-T cell therapies have made significant advances in hematological malignancies. This has led to segment saturation in terms the number of market players in this segment. To capitalize on untapped markets, many competitors have shifted their focus to the development of solid tumor treatments. Operational key stakeholders have lucrative opportunities in the development of an affordable, effective treatment for solid tumors.

The number of T-cell therapies for viral infections like HIV and COVID-19 has increased. Many CARs that target viral infections have made remarkable progress in the last few years. The clinical trial for anti-HIV CAR T cell therapy has been completed, while others like HCV and HBV are still in preclinical development. This will increase revenue for non-cancer indications.

Regional Insights

North America was the dominant market for T-cell therapy in 2020, accounting for around 40% of the total revenue. Strong research and a strong commercial base, combined with the high number of clinical trials for T-cell therapies being conducted in the U.S. have all contributed greatly to the dominance in this market.

The market has seen significant growth due to the growing number of regulatory approvals in Canada and the U.S., as well as the changing reimbursement system in the region. The regional market is also supported by the existence of numerous medical centers that offer CAR-T cells therapies.

China has been a promising market for CAR–T therapies in recent years. It hosts the largest number of clinical trials related to these therapies. The country has shown the highest CAGR due to its focus on reforms and government investment.

Market Share Insights & Key Companies

It is expected that the T-cell therapy market will be more competitive due to the increasing number of companies involved with the development of CAR–T therapies. Kite Pharma AG and Novartis AG are the leaders in T-cell therapy innovation and product development.

Juno Therapeutics and Adaptimmune are among the companies that are currently involved in developing T-cell therapies for various oncology indications.

Moreover, increasing investment flows have led to the entry of traditional drug developers like Merck KGaA, Pfizer and Amgen into this market. Sanofi's acquisition of Kiadis Pharma shows the increasing interest of international pharmaceutical companies in this area. The market leader in T-cell therapy is:

  • Novartis AG

  • Merck KGaA

  • Gilead Sciences Inc.

  • TCR2 Therapeutics Inc

  • Bluebird Bio Inc.

  • Sorrento Therapeutics

  • Fate Therapeutics

  • Pfizer Inc.

  • Amgen

  • Celgene Corporation

Up Market Research published a new report titled “T-cell Therapy Market research report which is segmented by Therapy (Tumor-Infiltrating Lymphocytes, CAR T-cell), by Indication (Hematologic Malignancies, Solid Tumors), By Players/Companies Gilead Sciences Inc, Sorrento Therapeutics, TCR2 Therapeutics Inc, Novartis AG, Amgen, Fate Therapeutics, Bluebird Bio Inc, Pfizer Inc, Celgene Corporation, Merck KGaA”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.


Report Scope

Report AttributesReport Details
Report TitleT-cell Therapy Market Research Report
By TherapyTumor-Infiltrating Lymphocytes, CAR T-cell
By IndicationHematologic Malignancies, Solid Tumors
By CompaniesGilead Sciences Inc, Sorrento Therapeutics, TCR2 Therapeutics Inc, Novartis AG, Amgen, Fate Therapeutics, Bluebird Bio Inc, Pfizer Inc, Celgene Corporation, Merck KGaA
Regions CoveredNorth America, Europe, APAC, Latin America, MEA
Base Year2020
Historical Year2018 to 2019 (Data from 2010 can be provided as per availability)
Forecast Year2028
Number of Pages204
Number of Tables & Figures143
Customization AvailableYes, the report can be customized as per your need.

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.


Global T-cell Therapy Industry Outlook

Global T-cell Therapy Market Report Segments:

The market is segmented by Therapy (Tumor-Infiltrating Lymphocytes, CAR T-cell), by Indication (Hematologic Malignancies, Solid Tumors).

T-cell Therapy Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.


Key Benefits for Industry Participants & Stakeholders:

  • Industry drivers, restraints, and opportunities covered in the study
  • Neutral perspective on the market performance
  • Recent industry trends and developments
  • Competitive landscape & strategies of key players
  • Potential & niche segments and regions exhibiting promising growth covered
  • Historical, current, and projected market size, in terms of value
  • In-depth analysis of the T-cell Therapy Market

Overview of the regional outlook of the T-cell Therapy Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.


T-cell Therapy Market Overview

Highlights of The T-cell Therapy Market Report:

  1. The market structure and projections for the coming years.
  2. Drivers, restraints, opportunities, and current trends of T-cell Therapy Market.
  3. Historical data and forecast.
  4. Estimations for the forecast period 2028.
  5. Developments and trends in the market.
        6. By Therapy:

                1. Tumor-Infiltrating Lymphocytes

                2. CAR T-cell

        7. By Indication:

                1. Hematologic Malignancies

                2. Solid Tumors

  1. Market scenario by region, sub-region, and country.
  2. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
  3. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
  4. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the T-cell Therapy Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.


How you may use our products:

  • Correctly Positioning New Products
  • Market Entry Strategies
  • Business Expansion Strategies
  • Consumer Insights
  • Understanding Competition Scenario
  • Product & Brand Management
  • Channel & Customer Management
  • Identifying Appropriate Advertising Appeals

T-cell Therapy Market Trends

Reasons to Purchase the T-cell Therapy Market Report:

  • The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
  • Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
  • Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
  • The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
  • Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.
Chapter 1 Executive Summary
Chapter 2 Assumptions and Acronyms Used
Chapter 3 Research Methodology
Chapter 4 T-cell Therapy Market Overview
   4.1 Introduction 
      4.1.1 Market Taxonomy 
      4.1.2 Market Definition 
      4.1.3 Macro-Economic Factors Impacting the Market Growth 
   4.2 T-cell Therapy Market Dynamics 
      4.2.1 Market Drivers 
      4.2.2 Market Restraints 
      4.2.3 Market Opportunity 
   4.3 T-cell Therapy Market - Supply Chain Analysis 
      4.3.1 List of Key Suppliers 
      4.3.2 List of Key Distributors 
      4.3.3 List of Key Consumers 
   4.4 Key Forces Shaping the T-cell Therapy Market 
      4.4.1 Bargaining Power of Suppliers 
      4.4.2 Bargaining Power of Buyers 
      4.4.3 Threat of Substitution 
      4.4.4 Threat of New Entrants 
      4.4.5 Competitive Rivalry 
   4.5 Global T-cell Therapy Market Size & Forecast, 2018-2028 
      4.5.1 T-cell Therapy Market Size and Y-o-Y Growth 
      4.5.2 T-cell Therapy Market Absolute $ Opportunity 


Chapter 5 Global T-cell Therapy Market Analysis and Forecast by Therapy
   5.1 Introduction
      5.1.1 Key Market Trends & Growth Opportunities by Therapy
      5.1.2 Basis Point Share (BPS) Analysis by Therapy
      5.1.3 Absolute $ Opportunity Assessment by Therapy
   5.2 T-cell Therapy Market Size Forecast by Therapy
      5.2.1 Tumor-Infiltrating Lymphocytes
      5.2.2 CAR T-cell
   5.3 Market Attractiveness Analysis by Therapy

Chapter 6 Global T-cell Therapy Market Analysis and Forecast by Indication
   6.1 Introduction
      6.1.1 Key Market Trends & Growth Opportunities by Indication
      6.1.2 Basis Point Share (BPS) Analysis by Indication
      6.1.3 Absolute $ Opportunity Assessment by Indication
   6.2 T-cell Therapy Market Size Forecast by Indication
      6.2.1 Hematologic Malignancies
      6.2.2 Solid Tumors
   6.3 Market Attractiveness Analysis by Indication

Chapter 7 Global T-cell Therapy Market Analysis and Forecast by Region
   7.1 Introduction
      7.1.1 Key Market Trends & Growth Opportunities by Region
      7.1.2 Basis Point Share (BPS) Analysis by Region
      7.1.3 Absolute $ Opportunity Assessment by Region
   7.2 T-cell Therapy Market Size Forecast by Region
      7.2.1 North America
      7.2.2 Europe
      7.2.3 Asia Pacific
      7.2.4 Latin America
      7.2.5 Middle East & Africa (MEA)
   7.3 Market Attractiveness Analysis by Region

Chapter 8 Coronavirus Disease (COVID-19) Impact 
   8.1 Introduction 
   8.2 Current & Future Impact Analysis 
   8.3 Economic Impact Analysis 
   8.4 Government Policies 
   8.5 Investment Scenario

Chapter 9 North America T-cell Therapy Analysis and Forecast
   9.1 Introduction
   9.2 North America T-cell Therapy Market Size Forecast by Country
      9.2.1 U.S.
      9.2.2 Canada
   9.3 Basis Point Share (BPS) Analysis by Country
   9.4 Absolute $ Opportunity Assessment by Country
   9.5 Market Attractiveness Analysis by Country
   9.6 North America T-cell Therapy Market Size Forecast by Therapy
      9.6.1 Tumor-Infiltrating Lymphocytes
      9.6.2 CAR T-cell
   9.7 Basis Point Share (BPS) Analysis by Therapy 
   9.8 Absolute $ Opportunity Assessment by Therapy 
   9.9 Market Attractiveness Analysis by Therapy
   9.10 North America T-cell Therapy Market Size Forecast by Indication
      9.10.1 Hematologic Malignancies
      9.10.2 Solid Tumors
   9.11 Basis Point Share (BPS) Analysis by Indication 
   9.12 Absolute $ Opportunity Assessment by Indication 
   9.13 Market Attractiveness Analysis by Indication

Chapter 10 Europe T-cell Therapy Analysis and Forecast
   10.1 Introduction
   10.2 Europe T-cell Therapy Market Size Forecast by Country
      10.2.1 Germany
      10.2.2 France
      10.2.3 Italy
      10.2.4 U.K.
      10.2.5 Spain
      10.2.6 Russia
      10.2.7 Rest of Europe
   10.3 Basis Point Share (BPS) Analysis by Country
   10.4 Absolute $ Opportunity Assessment by Country
   10.5 Market Attractiveness Analysis by Country
   10.6 Europe T-cell Therapy Market Size Forecast by Therapy
      10.6.1 Tumor-Infiltrating Lymphocytes
      10.6.2 CAR T-cell
   10.7 Basis Point Share (BPS) Analysis by Therapy 
   10.8 Absolute $ Opportunity Assessment by Therapy 
   10.9 Market Attractiveness Analysis by Therapy
   10.10 Europe T-cell Therapy Market Size Forecast by Indication
      10.10.1 Hematologic Malignancies
      10.10.2 Solid Tumors
   10.11 Basis Point Share (BPS) Analysis by Indication 
   10.12 Absolute $ Opportunity Assessment by Indication 
   10.13 Market Attractiveness Analysis by Indication

Chapter 11 Asia Pacific T-cell Therapy Analysis and Forecast
   11.1 Introduction
   11.2 Asia Pacific T-cell Therapy Market Size Forecast by Country
      11.2.1 China
      11.2.2 Japan
      11.2.3 South Korea
      11.2.4 India
      11.2.5 Australia
      11.2.6 South East Asia (SEA)
      11.2.7 Rest of Asia Pacific (APAC)
   11.3 Basis Point Share (BPS) Analysis by Country
   11.4 Absolute $ Opportunity Assessment by Country
   11.5 Market Attractiveness Analysis by Country
   11.6 Asia Pacific T-cell Therapy Market Size Forecast by Therapy
      11.6.1 Tumor-Infiltrating Lymphocytes
      11.6.2 CAR T-cell
   11.7 Basis Point Share (BPS) Analysis by Therapy 
   11.8 Absolute $ Opportunity Assessment by Therapy 
   11.9 Market Attractiveness Analysis by Therapy
   11.10 Asia Pacific T-cell Therapy Market Size Forecast by Indication
      11.10.1 Hematologic Malignancies
      11.10.2 Solid Tumors
   11.11 Basis Point Share (BPS) Analysis by Indication 
   11.12 Absolute $ Opportunity Assessment by Indication 
   11.13 Market Attractiveness Analysis by Indication

Chapter 12 Latin America T-cell Therapy Analysis and Forecast
   12.1 Introduction
   12.2 Latin America T-cell Therapy Market Size Forecast by Country
      12.2.1 Brazil
      12.2.2 Mexico
      12.2.3 Rest of Latin America (LATAM)
   12.3 Basis Point Share (BPS) Analysis by Country
   12.4 Absolute $ Opportunity Assessment by Country
   12.5 Market Attractiveness Analysis by Country
   12.6 Latin America T-cell Therapy Market Size Forecast by Therapy
      12.6.1 Tumor-Infiltrating Lymphocytes
      12.6.2 CAR T-cell
   12.7 Basis Point Share (BPS) Analysis by Therapy 
   12.8 Absolute $ Opportunity Assessment by Therapy 
   12.9 Market Attractiveness Analysis by Therapy
   12.10 Latin America T-cell Therapy Market Size Forecast by Indication
      12.10.1 Hematologic Malignancies
      12.10.2 Solid Tumors
   12.11 Basis Point Share (BPS) Analysis by Indication 
   12.12 Absolute $ Opportunity Assessment by Indication 
   12.13 Market Attractiveness Analysis by Indication

Chapter 13 Middle East & Africa (MEA) T-cell Therapy Analysis and Forecast
   13.1 Introduction
   13.2 Middle East & Africa (MEA) T-cell Therapy Market Size Forecast by Country
      13.2.1 Saudi Arabia
      13.2.2 South Africa
      13.2.3 UAE
      13.2.4 Rest of Middle East & Africa (MEA)
   13.3 Basis Point Share (BPS) Analysis by Country
   13.4 Absolute $ Opportunity Assessment by Country
   13.5 Market Attractiveness Analysis by Country
   13.6 Middle East & Africa (MEA) T-cell Therapy Market Size Forecast by Therapy
      13.6.1 Tumor-Infiltrating Lymphocytes
      13.6.2 CAR T-cell
   13.7 Basis Point Share (BPS) Analysis by Therapy 
   13.8 Absolute $ Opportunity Assessment by Therapy 
   13.9 Market Attractiveness Analysis by Therapy
   13.10 Middle East & Africa (MEA) T-cell Therapy Market Size Forecast by Indication
      13.10.1 Hematologic Malignancies
      13.10.2 Solid Tumors
   13.11 Basis Point Share (BPS) Analysis by Indication 
   13.12 Absolute $ Opportunity Assessment by Indication 
   13.13 Market Attractiveness Analysis by Indication

Chapter 14 Competition Landscape 
   14.1 T-cell Therapy Market: Competitive Dashboard
   14.2 Global T-cell Therapy Market: Market Share Analysis, 2019
   14.3 Company Profiles (Details – Overview, Financials, Developments, Strategy) 
      14.3.1 Gilead Sciences Inc
      14.3.2 Sorrento Therapeutics
      14.3.3 TCR2 Therapeutics Inc
      14.3.4 Novartis AG
      14.3.5 Amgen
      14.3.6 Fate Therapeutics
      14.3.7 Bluebird Bio Inc
      14.3.8 Pfizer Inc
      14.3.9 Celgene Corporation
      14.3.10 Merck KGaA
Segments Covered in the Report
The global T-cell Therapy market has been segmented based on

By Therapy
  • Tumor-Infiltrating Lymphocytes
  • CAR T-cell
By Indication
  • Hematologic Malignancies
  • Solid Tumors
Regions
  • Asia Pacific
  • North America
  • Latin America
  • Europe
  • Middle East & Africa
Key Players
  • Gilead Sciences Inc
  • Sorrento Therapeutics
  • TCR2 Therapeutics Inc
  • Novartis AG
  • Amgen
  • Fate Therapeutics
  • Bluebird Bio Inc
  • Pfizer Inc
  • Celgene Corporation
  • Merck KGaA

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