Global Stem Cells Market by Technology (Cryopreservation, Cell Acquisition), by Product (iPSCs, Adult, Mesenchymal) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

Summary of the Report

In 2020, the global stem cell market generated a revenue amounting to USD 9.38 billion. The market is expected to grow at 8.8% compound annual growth rate (CAGR), between 2021 and 2028. The growth is due to increasing demand for biologics and technological advances in stem cell therapy. There has also been a greater focus on the development personal medicines. Market expansion is due to the increasing emphasis on treating neurological disorders. According to the World Health Organization, neurological disorders and cerebrovascular diseases account for 7.1% of the global disease burden. Companies are therefore conducting preclinical and basic research to test the regenerative potential of stem cells for the treatment of neurological conditions.

Celavie Biosciences, for example, began its five-year exploratory study of Parkinson's disease in May 2020. The company is currently developing stem cell therapies to treat Parkinson's disease and central nervous system disorders. Celavie Biosciences has released positive results from their exploratory clinical trials with OK99 stem cells to treat Parkinson's disease.

The market is also growing due to personalized medicine, which is becoming more popular. New procurement methods are being developed by researchers that could be used to develop personalized medicines. iPSC therapies, for example, are made from a small sample of a patient's blood or skin cells that can later be reprogrammed to create new cells and tissue. These cells can then be used to develop personalized medicines.

Companies are also focusing their efforts on the development of therapies to reduce stress related to COVID-19. NoveCite Limited and Novellus Therapeutics Limited formed a partnership in October 2020 to develop and commercialize NoveCite iPSCs to treat COVID-19-associated Acute Respiratory Stress Syndrome (ARDS). This promising therapy is promising for acute respiratory conditions because it has multiple immunomodulatory mechanisms.

Product Insights

With a market share of 85.7%, the adult stem cells segment (ASCs), dominated 2020. This segment's dominance was due to the absence of controversial issues regarding ethics, immuno-rejection and tumorigenesis. Segment growth can also be attributed to the increasing use of ASCs in Regenerative Medicines. The process development of ASCs bioprocessing to regenerative medicine will be challenging.

Further, ASCs can be further divided into mesenchymal stem cell (MSCs), epithelial/skin cells, hematopoietic cells (HSCs), and neural stem cells. MSCs are expected to grow at the fastest rate of CAGR over the forecast period. This is due to their potential use for autologous transplantation, large clinical trials that have markedly demonstrated its effectiveness in treating various diseases, and extensive research into its therapeutic uses.

The induced pluripotent (iPSC) market is expected to grow at a significant 9.3% CAGR from 2021-2028. This is due to increased investment in developing regenerative medicines that use iPSC. It ensures reproducibility and maintenance, can differentiate into all cell types, and has high proliferative abilities. Companies are offering a variety of services related to iPSCs, due to their increasing importance in the treatment and prevention of many diseases.

REPROCELL, for example, launched the Personal "iPS" service in December 2020 to generate patient-specific IPSCs starting January 2021. This service can be used to prepare and store iPSCs of individuals for future treatment or illness. These are made from mature cells and incorporate ready-to-use RNA reprogramming technologies.

Application Insights

Regenerative medicine can be further subdivided into drug discovery and clinical development and drug discovery and treatment. Due to the increasing acceptance of stem cell therapies clinical trials for different diseases, regenerative medicine holds the largest market share at 89.1% in 2020. Longeveron LLC, for example, announced approval by Japan's Pharmaceutical and Medical Devices Agency for Phase 2 of a clinical trial to evaluate the safety and efficacy their Mesenchymal Stem Cells. (LMSCs) can be used to treat aging frailty.

Many governments also invest heavily in the development and testing of regenerative medicine. In March 2020, Canada spent approximately USD 6.9 million on regenerative medicine research. These funds will be used to fund 4 clinical trials as well as 9 translational projects that aim to develop new treatments in the regenerative medicine industry. The development of regenerative medicines will aid in the treatment and prevention of many diseases such as diabetes, heart disease, blood disorders, vision impairment, and blindness.

From 2021 to 2028, the lucrative segment of drug discovery and development is expected to see a 9.4% CAGR. Market products are gaining in popularity because they can be used to study human disease etiology and identify pathological mechanisms. They also help develop therapeutic strategies to tackle various diseases. Because they mimic the molecular and cellular phenotypes, iPSC-based models can be preferred to phenotypic screen. These models allow pharmaceutical companies to test hypothesized drug mechanisms in vitro at a low cost before undertaking clinical trials.

Therapy Insights

In 2020, allogenic stem cell therapy was responsible for the highest revenue share at 58.2%. Because of their ability to graft against cancer, allogeneic stem cells are widely used in the treatment and prevention of cancer. This effect allows stem cells from donors to use their immune system cells to kill cancer cells. The donor's immune system is more powerful than the recipient's. These are also commonly used to treat different types of cancers like lymphomas, leukemias and myelomas.

The forecast period will see autologous therapy grow at a high CAGR. This growth can be attributed largely to its advantages, such as fewer rejections of grafts and resulting in fewer complications. Other factors that contributed to the growth of this segment include high survival rates of patients, affordability and no need for HLA typing for matching donors. There is also low risk. The application of these cells can be made without the need for clinical trials or meeting stringent manufacturing standards.

Regional Insights

North America held 52.1% of the global market in 2020. This is due to several factors, including the presence of key players in stem cell therapy development, advanced healthcare infrastructure, substantial R&D, supportive reforms by healthcare organizations, and strong reimbursement policies. Due to high levels of research and government initiatives, the United States is the top country in the region.

Healthcare organizations promote the use of cell therapies for emerging diseases. In April 2020, for example, the U.S. Food and Drug Administration (FDA), authorized a clinical trial that tested the efficacy of umbilical cord-derived MSCs to prevent life-threatening lung inflammation in COVID-19 sufferers.

Asia Pacific is projected to grow at a 9.0% CAGR during the forecast year. This is due to the growing use of stem cells-based therapies, government initiatives to develop regenerative medicines and the establishment of multiple stem cell banks. There are also increasing clinical trials of regenerative medicine in the region. In July 2020, MEDIPOST released the results of NEUROSTEM's Phase 1/2a Study. It's an investigational stem-cell therapy that can be used to treat Alzheimer's disease.

Market Share Insights & Key Companies

Companies are increasingly receiving approvals for stem cell therapies. Mesoblast Ltd was approved by the U.S. FDA in April 2020 for an IND (Investigational New Drug Application for MSC Product Candidate remestemcel -L). It is used to treat patients with acute respiratory distress syndrome (ARDS), which is caused by COVID-19. The following are some of the key players in the global stem cell market:

• CELGENE CORPORATION

• ReNeuron Group plc

• Virgin Health Bank

• Biovault family

• Precious Cells International Ltd

• Mesoblast Ltd

• Caladrius

• Seneca Biopharmaceuticals, Inc.

• Opexa Therapeutics, Inc.

• Pluristem Therapeutics Inc

• STEMCELL Technologies Inc.

• ThermoGenesis Holdings, Inc

• Astellas Pharma Inc.

• Cellular Engineering Technologies

• BioTime, Inc.

Up Market Research published a new report titled “Stem Cells Market research report which is segmented by Technology (Cryopreservation, Cell Acquisition), by Product (iPSCs, Adult, Mesenchymal), By Players/Companies Celgene Corporation; STEMCELL Technologies Inc; BIOTIME, INC; Osiris Therapeutics Inc; Human Longevity Inc; Cynata; Cytori Therapeutics; Advanced Cell Technology Inc; Promethera Biosciences; and Mesoblast”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.

Report Scope

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.

Global Stem Cells Market Report Segments:

The market is segmented by Technology (Cryopreservation, Cell Acquisition), by Product (iPSCs, Adult, Mesenchymal).

Stem Cells Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.

Key Benefits for Industry Participants & Stakeholders:

• Industry drivers, restraints, and opportunities covered in the study
• Neutral perspective on the market performance
• Recent industry trends and developments
• Competitive landscape & strategies of key players
• Potential & niche segments and regions exhibiting promising growth covered
• Historical, current, and projected market size, in terms of value
• In-depth analysis of the Stem Cells Market

Overview of the regional outlook of the Stem Cells Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.

Highlights of The Stem Cells Market Report:

1. The market structure and projections for the coming years.
2. Drivers, restraints, opportunities, and current trends of Stem Cells Market.
3. Historical data and forecast.
4. Estimations for the forecast period 2028.
5. Developments and trends in the market.

                1. Cryopreservation

                2. Cell Acquisition

                1. iPSCs

                2. Adult

                3. Mesenchymal

8. Market scenario by region, sub-region, and country.
9. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
10. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
11. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the Stem Cells Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.

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Reasons to Purchase the Stem Cells Market Report:

• The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
• Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
• Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
• The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
• Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.