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Global Protein Labeling Market by Product (Probes/Tags, Enzymes), by Application (Mass Spectrometry, Cell-based Assays) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

  • Report ID: NT-73418
  • Author: Up Market Research
  • Rating: 5.0
  • Total Reviews: 55
  • No. Of Pages: 205
  • Format:
  • Pub. Date: 2021-10-21
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Summary of the Report

Global protein labeling market was valued at USD 1.8 Billion in 2019. It is projected to grow at a compound annual rate (CAGR), of 7.2% between 2020 and 2027. The demand for protein labels is driven by an increase in R&D spending on proteomics research. The proteomics research field has seen an increase in R&D spending, which has led to a greater use of protein microarray and mass spectrometry. Additionally, the growth in organic revenue from the market is driven by improvements in mass-spectrometry workflows, and the miniaturization biochips.

The discovery of new biomarkers is being accelerated by an increase in R&D spending. Large-scale proteomics and genomics research has boosted the amount of proteomic information. The use of proteomics research is also supported by an increase in drugs in the R&D pipeline. In 2019, there were approximately 16,181 drugs in the R&D pipeline, which was almost 2.7% more than in 2018.

Modern molecular biology tools and bioengineering tools are being used to improve drug development, diagnosis, therapy, and application. The use of bioengineering tools has led to a significant increase in the use of labels for the detection and purification of proteins, as well as diagnostic tests that are based on the detection or absence of a specific protein.

In proteomics and biotechnology, the use of non-canonical amino acids (ncAAs), followed by conjugation with labeled proteins, with fluorophores or polymers, affinity, reagents, nanoparticles, or fluorophores has been proven to be highly effective. These ncAA-labeled proteins are enhanced with cells and tissues. These bioengineered tools will be used to analyze protein dynamics in time and space, and also to engineer novel chemistries.

Market growth is likely to be facilitated by mass spectrometry's advancements in biomarker identification, quantification and disease prognosis. These advancements include Surface-Enhanced Laser Desorption/Ionization, which is an alternative version of Matrix-Assisted Laser Desorption/Ionization where the analyte binds to a surface before mass analysis. This is useful for detecting the rate of progression of gastric cancer.

Product Insights

With a 64.9% revenue share in 2019, reagents dominated market for protein-labeling. The estimated share of reagents in the market for protein labeling is due to an increase in the number and types of genetically engineered labels. The commercial availability of efficient reagents such as No-Stain Protein Labeling Resagent, which allows for accurate and reliable normalization and protein visualization, has positively impacted the segment's growth.

The market share for protein labeling was the largest in the reagent segment. Monomeric fluorescent proteins, which address the issues of aggregation due to electrostatic and hydrophobic interactions between the fluorescent protein host and fluorescent protein, can explain this. For the development of monomeric products, market participants such as Addgene, Allele Biotechnology and Allele Biotechnology are cooperating.

However, probes/tags will likely experience the fastest growth rates during the forecast period. Different tags can be used to label membrane-peptide molecules in super-resolution microscopy. Many reagent manufacturers are also working to develop peptide-based affinity agents to increase tag specificities. This strategy is expected to lead to a greater number of probes and tags in the future.

Application Insights

The market leader in protein labeling was the immunological techniques segment. It accounted for 40.3% of the highest revenue share in 2019 and is still the most dominant. In 2019, the segment generated a maximum revenue share of USD 716.5. The majority of immunological techniques, such as flow-cytometry, immunoassays and western blotting, require labels to be used. These techniques are used extensively in cancer research, autoimmune disease research, and the development of therapeutics.

These techniques are also widely accepted for the detection of diabetes and systemic lupus-erythematosus. This segment has a higher revenue share due to wider use of immunological techniques. Estimated revenue share can also be attributed to the use of immunoelectron microscopic for defining antigen positions at resolutions of 10 nanometers and finer.

Fluorescence microscopy has seen rapid growth due to the rapid development of fluorescence microscopy, which allows for detailed biological analysis of cell pathways in academic research. This technique has many advantages over traditional microscopy, as it can analyze large numbers of samples at high speed and provides unbiased methods to capture images.

Method Insights

In-vitro methods had a 69.8% revenue share in 2019, and they are expected to continue growing at a rapid pace. Enzymatic labeling was the most popular method due to its highly specific action. The covalent site-specific binding to an enzyme facilitates the incorporation bio-orthogonal functionalities in proteins. This allows for site-specific protein engineering and labeling.

In-vitro nanoparticle-based methods will experience the fastest CAGR between 2020 and 2027. This involves the use of nanoparticles (especially gold nanoparticles), which can be linked to antibodies or hinge thiols on IgG and Fab. Because of their small size, nanoparticles can reach difficult places and form covalent bonds to the target protein or other peptide. This allows for better labeling and stability.

This method provides ultra-stability and prevents metal-antibody interactions. It also offers ultra-sensitivity during protein quantification and detection. Covalent conjugation and passive adsorption are the most common strategies used for labeling peptide molecules with gold nanoparticles. Easy conjugation of gold nanoparticles is another reason why it is highly sought after in R&D and manufacturing of diagnostic kits.

Regional Insights

North America was the market leader in protein labeling, with 46.8% of the total market share in 2019. This region has seen a significant increase in research using immunological techniques, fluorescence microscopes, cell-based assays, and western blotting. This has led to a larger revenue share. Region's revenue generation is also fueled by the high use of protein labeling in disease diagnosis-related studies.

In August 2019, researchers at the National Institutes of Health (U.S.) published a study that demonstrated how a bi-arsenical system of dyes can be used to detect proteins in different cells. This technology provided new opportunities for investigating the morphology, motility, and causes of Lyme disease and leptospirosis in Borrelia and Leptospira species.

The Asia Pacific market for protein labeling will experience a significant growth rate over the forecast period. The region's ongoing research projects in proteomics are responsible for this growth. Among the many ongoing projects in Japan are: The Structural Proteomics Project and Proteome Expression Database, Genome Medicine Database Of Japan Proteomics and Structural Genomics.

Market Share Insights & Key Companies

The market for protein labeling has seen a lot of business expansions over the years. Perkin Elmer acquired Cisbio Bioassays in April 2019 to expand its DELFIA and Alpha assay technologies. PerkinElmer acquired Cisbio to expand its capabilities, giving researchers greater access to a wider range of tools for small-molecule and biologic drug discovery. The market leader in protein labeling is:

  • Thermo Fisher Scientific, Inc.

  • Merck KGaA

  • Perkin Elmer, Inc.

  • Promega Corporation

  • F. Hoffmann-La Roche Ltd.

  • LGC Limited

  • New England Biolabs

  • LI-COR, Inc.

  • GE Healthcare

  • Jena Bioscience GmbH

Up Market Research published a new report titled “Protein Labeling Market research report which is segmented by Product (Probes/Tags, Enzymes), by Application (Mass Spectrometry, Cell-based Assays), By Players/Companies GE Healthcare, Promega Corporation, New England Biolabs, Merck KGaA, Thermo Fisher Scientific Inc, F Hoffmann-La Roche Ltd, LI-COR Inc, Perkin Elmer Inc, LGC Limited, Jena Bioscience GmbH”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.


Report Scope

Report AttributesReport Details
Report TitleProtein Labeling Market Research Report
By ProductProbes/Tags, Enzymes
By ApplicationMass Spectrometry, Cell-based Assays
By CompaniesGE Healthcare, Promega Corporation, New England Biolabs, Merck KGaA, Thermo Fisher Scientific Inc, F Hoffmann-La Roche Ltd, LI-COR Inc, Perkin Elmer Inc, LGC Limited, Jena Bioscience GmbH
Regions CoveredNorth America, Europe, APAC, Latin America, MEA
Base Year2020
Historical Year2018 to 2019 (Data from 2010 can be provided as per availability)
Forecast Year2028
Number of Pages205
Number of Tables & Figures144
Customization AvailableYes, the report can be customized as per your need.

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.


Global Protein Labeling Industry Outlook

Global Protein Labeling Market Report Segments:

The market is segmented by Product (Probes/Tags, Enzymes), by Application (Mass Spectrometry, Cell-based Assays).

Protein Labeling Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.


Key Benefits for Industry Participants & Stakeholders:

  • Industry drivers, restraints, and opportunities covered in the study
  • Neutral perspective on the market performance
  • Recent industry trends and developments
  • Competitive landscape & strategies of key players
  • Potential & niche segments and regions exhibiting promising growth covered
  • Historical, current, and projected market size, in terms of value
  • In-depth analysis of the Protein Labeling Market

Overview of the regional outlook of the Protein Labeling Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.


Protein Labeling Market Overview

Highlights of The Protein Labeling Market Report:

  1. The market structure and projections for the coming years.
  2. Drivers, restraints, opportunities, and current trends of Protein Labeling Market.
  3. Historical data and forecast.
  4. Estimations for the forecast period 2028.
  5. Developments and trends in the market.
        6. By Product:

                1. Probes/Tags

                2. Enzymes

        7. By Application:

                1. Mass Spectrometry

                2. Cell-based Assays

  1. Market scenario by region, sub-region, and country.
  2. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
  3. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
  4. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the Protein Labeling Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.


How you may use our products:

  • Correctly Positioning New Products
  • Market Entry Strategies
  • Business Expansion Strategies
  • Consumer Insights
  • Understanding Competition Scenario
  • Product & Brand Management
  • Channel & Customer Management
  • Identifying Appropriate Advertising Appeals

Protein Labeling Market Trends

Reasons to Purchase the Protein Labeling Market Report:

  • The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
  • Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
  • Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
  • The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
  • Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.
Chapter 1 Executive Summary
Chapter 2 Assumptions and Acronyms Used
Chapter 3 Research Methodology
Chapter 4 Protein Labeling Market Overview
   4.1 Introduction 
      4.1.1 Market Taxonomy 
      4.1.2 Market Definition 
      4.1.3 Macro-Economic Factors Impacting the Market Growth 
   4.2 Protein Labeling Market Dynamics 
      4.2.1 Market Drivers 
      4.2.2 Market Restraints 
      4.2.3 Market Opportunity 
   4.3 Protein Labeling Market - Supply Chain Analysis 
      4.3.1 List of Key Suppliers 
      4.3.2 List of Key Distributors 
      4.3.3 List of Key Consumers 
   4.4 Key Forces Shaping the Protein Labeling Market 
      4.4.1 Bargaining Power of Suppliers 
      4.4.2 Bargaining Power of Buyers 
      4.4.3 Threat of Substitution 
      4.4.4 Threat of New Entrants 
      4.4.5 Competitive Rivalry 
   4.5 Global Protein Labeling Market Size & Forecast, 2018-2028 
      4.5.1 Protein Labeling Market Size and Y-o-Y Growth 
      4.5.2 Protein Labeling Market Absolute $ Opportunity 


Chapter 5 Global Protein Labeling Market Analysis and Forecast by Product
   5.1 Introduction
      5.1.1 Key Market Trends & Growth Opportunities by Product
      5.1.2 Basis Point Share (BPS) Analysis by Product
      5.1.3 Absolute $ Opportunity Assessment by Product
   5.2 Protein Labeling Market Size Forecast by Product
      5.2.1 Probes/Tags
      5.2.2 Enzymes
   5.3 Market Attractiveness Analysis by Product

Chapter 6 Global Protein Labeling Market Analysis and Forecast by Application
   6.1 Introduction
      6.1.1 Key Market Trends & Growth Opportunities by Application
      6.1.2 Basis Point Share (BPS) Analysis by Application
      6.1.3 Absolute $ Opportunity Assessment by Application
   6.2 Protein Labeling Market Size Forecast by Application
      6.2.1 Mass Spectrometry
      6.2.2 Cell-based Assays
   6.3 Market Attractiveness Analysis by Application

Chapter 7 Global Protein Labeling Market Analysis and Forecast by Region
   7.1 Introduction
      7.1.1 Key Market Trends & Growth Opportunities by Region
      7.1.2 Basis Point Share (BPS) Analysis by Region
      7.1.3 Absolute $ Opportunity Assessment by Region
   7.2 Protein Labeling Market Size Forecast by Region
      7.2.1 North America
      7.2.2 Europe
      7.2.3 Asia Pacific
      7.2.4 Latin America
      7.2.5 Middle East & Africa (MEA)
   7.3 Market Attractiveness Analysis by Region

Chapter 8 Coronavirus Disease (COVID-19) Impact 
   8.1 Introduction 
   8.2 Current & Future Impact Analysis 
   8.3 Economic Impact Analysis 
   8.4 Government Policies 
   8.5 Investment Scenario

Chapter 9 North America Protein Labeling Analysis and Forecast
   9.1 Introduction
   9.2 North America Protein Labeling Market Size Forecast by Country
      9.2.1 U.S.
      9.2.2 Canada
   9.3 Basis Point Share (BPS) Analysis by Country
   9.4 Absolute $ Opportunity Assessment by Country
   9.5 Market Attractiveness Analysis by Country
   9.6 North America Protein Labeling Market Size Forecast by Product
      9.6.1 Probes/Tags
      9.6.2 Enzymes
   9.7 Basis Point Share (BPS) Analysis by Product 
   9.8 Absolute $ Opportunity Assessment by Product 
   9.9 Market Attractiveness Analysis by Product
   9.10 North America Protein Labeling Market Size Forecast by Application
      9.10.1 Mass Spectrometry
      9.10.2 Cell-based Assays
   9.11 Basis Point Share (BPS) Analysis by Application 
   9.12 Absolute $ Opportunity Assessment by Application 
   9.13 Market Attractiveness Analysis by Application

Chapter 10 Europe Protein Labeling Analysis and Forecast
   10.1 Introduction
   10.2 Europe Protein Labeling Market Size Forecast by Country
      10.2.1 Germany
      10.2.2 France
      10.2.3 Italy
      10.2.4 U.K.
      10.2.5 Spain
      10.2.6 Russia
      10.2.7 Rest of Europe
   10.3 Basis Point Share (BPS) Analysis by Country
   10.4 Absolute $ Opportunity Assessment by Country
   10.5 Market Attractiveness Analysis by Country
   10.6 Europe Protein Labeling Market Size Forecast by Product
      10.6.1 Probes/Tags
      10.6.2 Enzymes
   10.7 Basis Point Share (BPS) Analysis by Product 
   10.8 Absolute $ Opportunity Assessment by Product 
   10.9 Market Attractiveness Analysis by Product
   10.10 Europe Protein Labeling Market Size Forecast by Application
      10.10.1 Mass Spectrometry
      10.10.2 Cell-based Assays
   10.11 Basis Point Share (BPS) Analysis by Application 
   10.12 Absolute $ Opportunity Assessment by Application 
   10.13 Market Attractiveness Analysis by Application

Chapter 11 Asia Pacific Protein Labeling Analysis and Forecast
   11.1 Introduction
   11.2 Asia Pacific Protein Labeling Market Size Forecast by Country
      11.2.1 China
      11.2.2 Japan
      11.2.3 South Korea
      11.2.4 India
      11.2.5 Australia
      11.2.6 South East Asia (SEA)
      11.2.7 Rest of Asia Pacific (APAC)
   11.3 Basis Point Share (BPS) Analysis by Country
   11.4 Absolute $ Opportunity Assessment by Country
   11.5 Market Attractiveness Analysis by Country
   11.6 Asia Pacific Protein Labeling Market Size Forecast by Product
      11.6.1 Probes/Tags
      11.6.2 Enzymes
   11.7 Basis Point Share (BPS) Analysis by Product 
   11.8 Absolute $ Opportunity Assessment by Product 
   11.9 Market Attractiveness Analysis by Product
   11.10 Asia Pacific Protein Labeling Market Size Forecast by Application
      11.10.1 Mass Spectrometry
      11.10.2 Cell-based Assays
   11.11 Basis Point Share (BPS) Analysis by Application 
   11.12 Absolute $ Opportunity Assessment by Application 
   11.13 Market Attractiveness Analysis by Application

Chapter 12 Latin America Protein Labeling Analysis and Forecast
   12.1 Introduction
   12.2 Latin America Protein Labeling Market Size Forecast by Country
      12.2.1 Brazil
      12.2.2 Mexico
      12.2.3 Rest of Latin America (LATAM)
   12.3 Basis Point Share (BPS) Analysis by Country
   12.4 Absolute $ Opportunity Assessment by Country
   12.5 Market Attractiveness Analysis by Country
   12.6 Latin America Protein Labeling Market Size Forecast by Product
      12.6.1 Probes/Tags
      12.6.2 Enzymes
   12.7 Basis Point Share (BPS) Analysis by Product 
   12.8 Absolute $ Opportunity Assessment by Product 
   12.9 Market Attractiveness Analysis by Product
   12.10 Latin America Protein Labeling Market Size Forecast by Application
      12.10.1 Mass Spectrometry
      12.10.2 Cell-based Assays
   12.11 Basis Point Share (BPS) Analysis by Application 
   12.12 Absolute $ Opportunity Assessment by Application 
   12.13 Market Attractiveness Analysis by Application

Chapter 13 Middle East & Africa (MEA) Protein Labeling Analysis and Forecast
   13.1 Introduction
   13.2 Middle East & Africa (MEA) Protein Labeling Market Size Forecast by Country
      13.2.1 Saudi Arabia
      13.2.2 South Africa
      13.2.3 UAE
      13.2.4 Rest of Middle East & Africa (MEA)
   13.3 Basis Point Share (BPS) Analysis by Country
   13.4 Absolute $ Opportunity Assessment by Country
   13.5 Market Attractiveness Analysis by Country
   13.6 Middle East & Africa (MEA) Protein Labeling Market Size Forecast by Product
      13.6.1 Probes/Tags
      13.6.2 Enzymes
   13.7 Basis Point Share (BPS) Analysis by Product 
   13.8 Absolute $ Opportunity Assessment by Product 
   13.9 Market Attractiveness Analysis by Product
   13.10 Middle East & Africa (MEA) Protein Labeling Market Size Forecast by Application
      13.10.1 Mass Spectrometry
      13.10.2 Cell-based Assays
   13.11 Basis Point Share (BPS) Analysis by Application 
   13.12 Absolute $ Opportunity Assessment by Application 
   13.13 Market Attractiveness Analysis by Application

Chapter 14 Competition Landscape 
   14.1 Protein Labeling Market: Competitive Dashboard
   14.2 Global Protein Labeling Market: Market Share Analysis, 2019
   14.3 Company Profiles (Details – Overview, Financials, Developments, Strategy) 
      14.3.1 GE Healthcare
      14.3.2 Promega Corporation
      14.3.3 New England Biolabs
      14.3.4 Merck KGaA
      14.3.5 Thermo Fisher Scientific Inc
      14.3.6 F Hoffmann-La Roche Ltd
      14.3.7 LI-COR Inc
      14.3.8 Perkin Elmer Inc
      14.3.9 LGC Limited
      14.3.10 Jena Bioscience GmbH
Segments Covered in the Report
The global Protein Labeling market has been segmented based on

By Product
  • Probes/Tags
  • Enzymes
By Application
  • Mass Spectrometry
  • Cell-based Assays
Regions
  • Asia Pacific
  • North America
  • Latin America
  • Europe
  • Middle East & Africa
Key Players
  • GE Healthcare
  • Promega Corporation
  • New England Biolabs
  • Merck KGaA
  • Thermo Fisher Scientific Inc
  • F Hoffmann-La Roche Ltd
  • LI-COR Inc
  • Perkin Elmer Inc
  • LGC Limited
  • Jena Bioscience GmbH

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