Global primary cell culture market was valued at USD 3.34 billion in 2020. It is projected to grow at a compound annual rate of 11.6% between 2021 and 2028. Market growth is primarily due to an increase in chronic conditions such as cancer, infections and diabetes mellitus. This has facilitated the adoption of primary cells cultures, which has resulted in an increase in research.
According to the American Cancer Society (2020), there will be 16.9 million survivors/patients of cancer. According to WHO (2020), 71.0 millions people are living with chronic hepatitis C. The rising prevalence of chronic diseases is driving demand for advanced treatments, which will drive market growth over the next few years.
The market for primary cells culture can also be attributed to an increase in the use of primary cell cultures for drug screening and in-vitro testing. They are derived from tissue, which allows researchers to examine cellular structure and normal functioning in the in-vivo state. They are therefore used to study cell biochemistry, physiology, signaling studies, metabolic processes, and the effects of toxic compounds and drug.
The COVID-19 pandemic has been a positive catalyst to the expansion of primary cell culture markets. Primary cell culture is increasingly being used by researchers to understand the infection. The use of standardized and characterized epithelium cell-culture models is helping to understand the physical barrier that was destroyed by the coronavirus. These models are able to mimic the functions and properties in the respiratory tract. This can lead to medical applications.
The primary immune cell culture was also proven to be extremely beneficial in the study and production of antibodies and antigens by the COVID-19virus. The German Primate Center in Gottingen has found that the COVID-19 virus can block infection of lung cells by using TMPRSS2, which is an inhibitor for serine protease. These results were confirmed by the primary cell culture experiment.
In 2020, the largest share of revenue was 34.0% for the reagents & supplements segment in the primary cell culture market. This segment has seen a steady increase in sales due to its regular use in primary cell culture research and manufacturing. Primary cells are fragile and require reagents or supplements to grow.
The segment is also being impacted by the creation of new products like growth factors and cytokines. In October 2020, iBio, Inc., a U.S-based biotechnology company, entered into a strategic agreement for the development growth factors and cytokines with Safi Biosolutions, Inc.
Over the forecast period, the primary cells segment will experience the fastest CAGR at 11.8%. This is due to the increasing number of primary cells that can be used for different diseases. In February 2021, Garvan Institute of Medical Research researchers discovered a new bone cell type which could lead to new therapeutic targets for osteoporosis. These robust research efforts are expected to greatly boost the growth of the segment.
Enzymatic degradation was the dominant segment in the primary cell culture market and had a 33.3% revenue share in 2020. This segment holds a large market share due to its preference over other methods for separating primary cells. It has the following advantages: less damage to cultures; comparatively fast; high yield of representative samples.
Trypsin was the dominant market leader in primary cell culture revenue in 2020, owing to its high use for enzyme disaggregation. This enzyme is widely used for the dissociation and processing of adhesive cells in flasks and rapid passage of large cell suspension.
Due to technological advances in mechanical separation, the segment of mechanical separation is expected to see a profitable CAGR of 11.7% during the forecast period. In October 2020, researchers from France used mechanical extraction and immuno-magnetic cell sorting to culture primary skin cells taken from patients with systemic sclerosis. This technique was found to have a higher purity rate than conventional methods for human dermal microvascular cells.
In 2020, the vaccine production segment held 12.2% of the total revenue. It dominated the primary cell culture market. This is due to an increasing use of primary animal culture for virus production, which is later used for several vaccines like measles and hepatitis B. This has resulted in a cost reduction due to the use of animal models as vaccine testing.
Over the forecast period, the stem cell therapy market is expected to grow at a profitable CAGR of 11.9%. This segment has seen a lot of interest from scientists around the globe to conduct various research projects using cells. Researchers are changing the way they perceive primary cells through research using adult, embryonic and induced stem cells. Stem cell-based therapies also have great potential and are being used in neurodegenerative diseases and other conditions such as diabetes, eye diseases, retinal diseases, and dentistry. Market growth is expected to continue as these therapies are increasingly used.
Animal cells dominated the primary cell culture market and was responsible for 58.6% of the total revenue in 2020. The segment's growth is largely due to the increasing use of primary cells from animals for vaccine development. For the development of vaccines against measles and rabies, as well as chickenpox and hepatitis B, primary cultures derived from animals have been used.
Segment growth can also be attributed to the large product range of animal-origin prima cells offered by companies like Lonza, Merck KGaA, and Thermo Fisher Scientific, Inc. These include hepatocytes, hepatocytes, keratinocytes, immune, hematopoietic and mesangial stem cells, as well as rat, monkey, and mouse-derived fibroblasts.
Over the forecast period, significant growth is expected in the human cells segment. This is mainly due to the increasing use of human-derived primaries cultures for cancer research. Primary human cancer cells can be derived from many tissue types, including brain, muscle, connective tissue, to allow for the physiologically relevant study on cancer. These cultures are able to be used for clinical and preclinical analyses as well as clinical studies in the field of cancer research.
North America was the dominant market for primary cell culture and held 52.6% of the total revenue share in 2020. This trend is expected to continue over the forecast period. This region's growth can be attributed in part to its high healthcare spending, increasing geriatric population, rising prevalence of chronic diseases, and support from government funding. Market growth is also being driven by the increased focus of market players on innovating cell culture applications, instrumentation and the availability of various types of cells as well as their cellular interactions.
Asia Pacific will be the fastest growing region during the forecast period. This is due to the low cost of stem cell transplantation in this region, which has contributed to the high demand. Research is also ongoing, which can further be attributed to the region’s growth. In March 2020, for example, the Centre for Disease Control in China (CDC) grew lung cells using human tissue culture systems to spread SARS-CoV-2.
These companies are developing new products for primary cell cultivation. Thermo Fisher Scientific Inc., for example, launched a new medium to expand human T lymphocytes in January 2021 for allogeneic cell therapy. The new Gibco CTS OpTmizer PRO SFM aids in increasing donor T (lymphocyte cell) proliferation. This media solution is designed to target the metabolism of healthy donors and produce cost-effective cell therapies. The following are some of the major players in the primary cell-culture market:
Thermo Fisher Scientific, Inc.
Lonza
Merck
Corning Incorporated
Danaher
PromoCell GmbH
ATCC
FUJIFILM Irvine Scientific, Inc.
Mattek
Axol Bioscience Ltd.
Up Market Research published a new report titled “Primary Cell Culture Market research report which is segmented by Application (Vaccine Production, Virology), by Product (Media, Reagents & Supplements), By Players/Companies Merck, Mattek, FUJIFILM Irvine Scientific Inc, PromoCell GmbH, Lonza, Thermo Fisher Scientific Inc, Axol Bioscience Ltd, Danaher  , ATCC, Corning Incorporated”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.
Report Attributes | Report Details |
Report Title | Primary Cell Culture Market Research Report |
By Application | Vaccine Production, Virology |
By Product | Media, Reagents & Supplements |
By Companies | Merck, Mattek, FUJIFILM Irvine Scientific Inc, PromoCell GmbH, Lonza, Thermo Fisher Scientific Inc, Axol Bioscience Ltd, Danaher  , ATCC, Corning Incorporated |
Regions Covered | North America, Europe, APAC, Latin America, MEA |
Base Year | 2020 |
Historical Year | 2018 to 2019 (Data from 2010 can be provided as per availability) |
Forecast Year | 2028 |
Number of Pages | 209 |
Number of Tables & Figures | 147 |
Customization Available | Yes, the report can be customized as per your need. |
The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.
The market is segmented by Application (Vaccine Production, Virology), by Product (Media, Reagents & Supplements).
Primary Cell Culture Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.
Key Benefits for Industry Participants & Stakeholders:
Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.
We have studied the Primary Cell Culture Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.
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