Global nucleic acid labeling market was valued at USD 1.64 Billion in 2019. It is projected to grow at an 8.81% compound annual growth rate (CAGR), between 2020 and 2027. The development of new genomic research platforms and the increasing prevalence of molecular diseases that require the use of nucleic acids-based detection techniques are key growth drivers. The market is expected to see an increase in penetration of nucleic acids labels across DNA microarrays. This will further boost the market growth between 2020 and 2027. With the growing number of commercial producers and advanced product offerings for nucleic acids detection, the industry's revenue generation potential is enhanced.
The nanotechnology industry has made significant advances in point-of-care (POC-based) nucleic acid detection. POC solutions can be used to detect RNA and DNA in portable formats. It is a popular choice for professionals working in a variety of healthcare areas, including on-site detection and patient side diagnostics. These lines of research include the review of recent innovations that focus on read-out modalities and sample preparation. Point-of-care nucleic acids detection will gain tremendous traction with the development of new nanotechnology solutions. This will drive the market.
Professionals must consider several factors when choosing a labeling system. These factors include the desired detection method, hybridization method, resolution and sensitivity, as well as the method used to incorporate a particular label. They also need to consider stability after labeling. The type and size (or combination thereof) of the nucleic acids are crucial in determining the best labeling system or protocol. Random labels can be used to label RNA for blots and large DNA.
These covalent probes have excellent sensitivity. Enzymatic labeling, which involves multi-labeling the sample using PCR methods, is an economically viable option for laboratory professionals. For shorter sequences, such as those of oligonucleotides or PCR, it is a benefit to order a sample already labeled. Several companies, such as Genewiz and Integrated DNA Technologies, Inc., offer pre-labeled DNA.
Prenatal testing, disease risk management and the detection of infectious diseases is made possible by nucleic acid-based diagnostics. They are quick to respond. Healthcare professionals are also keen to invest in products that use nucleic acids analytics, due to the increasing prevalence of genetic disorders. The market expansion will be further impeded by the inability of nucleic acid labeling professionals to utilize the new equipment and systems.
In 2019, the largest share was held by the reagents sector, which accounted for 42.77%. This is due to the high cost and frequent usage of reagents in chemical and enzymatic labels. These reagents are dominant due to their recurrent use in labeling protocols. This is followed by ongoing developments in this area to improve the efficiency of these protocols. Chemical methods are useful for large-scale nucleic acids labeling. Enzymatic methods, however, have proved to be more cost-effective for small-scale probe generation applications. Both methods routinely make use of both conventional and new enzymes.
Kits will be the most lucrative segment with a CAGR in excess of 9.33% between 2020 and 2027. The market is seeing more manufacturers focusing on creating kits that can be used for a variety of applications. This will allow them to introduce cutting-edge nucleic acids labeling kits. Vector Laboratories is one such manufacturer. Vector Laboratories makes 5' E’ ndTag/3’ E’ ndTag kits for attaching an affinity tag or one fluorochrome to the desired end of nucleic acid. The company manufactures a 5' E ndTag labeling kit that uses both DNA and RNA as a substrate. The 3' E ndTag kit labels DNA selectively.
In 2019, the radioactive labels segment was responsible for 65.97% of the total. The radiolabeled nucleotides segment is the most popular in many applications that deal with nucleic acids sequences. These nucleic acids sequences can be incorporated into DNA and RNA using enzyme-based analytical methods. There are many other ways that the labeled sequences of nucleic acids can be integrated, including in vitro transcription methods via T7 orT3 RNA polymerase, SP6, DNAse 1 and DNA Polymerase 1 via nick translation, among others.
Because of their safety, sensitivity, relative speed, versatility, and ease-of-use, non-radioactive nucleotide tags are being extensively used at the moment. Fluorescent tags are also a popular choice. These tags are synthesized and then incorporated in oligonucleotides. This has been useful for many therapeutic purposes. These tags can be attached to different proteins, molecules and chemically active groups, such as streptavidin or biotin.
In 2019, the enzyme-based method segment was responsible for 57.10% of the overall market share. This is cumulative revenue generated through PCR, 5' and 3' end labels, as well as other enzyme-based methods. It is the most popular method for producing small-scale probes and it has a high acceptance. The economic approach of enzyme-based methods is also possible.
There are many chemical and enzymatic methods that can be used to produce labeled nucleic acids. These include radioactive phosphates and fluorophores. Enzymes and digoxygenin/biotin-modified nucleotides. To keep up with the increasing industry competition, companies in the nucleic acids labeling market want to expand their product range. The bioconjugation method used to create nucleic acid probes is also preferred. This allows for the attachment of nucleic acids on certain molecules or surfaces. It facilitates targeted delivery and immobilization.
The selection of the right labeling method depends partly on the desired degree and the predictable reactions that result from modifications. Both chemical and enzymatic approaches can yield nucleic acid, which can be labeled at 3? 3? oder 5? End of the oligonucleotide. These approaches also gain command over probe integration protocols that are applied to a specific sequence.
In-situ Hybridization was the dominant method of hybridization, accounting for more than 30.0%. With the increase in use of ISH techniques for diagnosing genetic disorders such as Cri-du–chat, 22q13 deletion, Angelman syndrome and Velocardiofacial Syndrome, Prader-Willi, Down syndrome, and chronic myelogenous Leukemia (CML), nucleic acid labeling will be in demand.
For in-vitro experiments using polymerase chain reaction, nucleic acids that have been labeled with nucleotide Triphosphates or deoxynucleotide Triphosphates are preferred. In addition, probes with end labels have been in great demand for experiments related to protein interactions, particularly gel-shift assays.
In 2019, the diagnostics segment held the largest share at 39.79% and will continue to hold that position throughout the forecast period. Research is expected to experience the fastest growth between 2020 and 2027. This can be attributed to the extended use of nucleic acids labels across their purification and visualization, further aiding in the diagnosis of specific sequences suitable fo in-situ hybridization. Radioisotope labeling nucleic acid has also gained popularity in clinical and research studies related to cancer diagnostics.
The importance of nucleic acid labeling is being recognized for better understanding and visualization biological processes. Nucleic acid labeling is being used in a variety of cell-based applications. This allows for insight into specific cycloadditions or bioorthogonal chemical reactions that occur within cells. Nucleic acid labeling products have a wide range of applications, including research, diagnosis, therapy, and research.
North America dominated the market with a 39.47% share in 2019. It is expected to continue its dominance over the forecast period. The region's strong presence of market leaders and a developed healthcare infrastructure are key factors in its market growth.
The Asia Pacific market will experience the fastest growth rate over the forecast period. This is due to the growth of local players as well as the penetration of key players within the Asia Pacific region. These companies are leveraging the opportunity to offer a variety of labeling solutions for developing countries.
This region has seen a rise in inter-regional collaborations between key entities, which further fuels market growth. These partnerships are primarily aimed at the improvement of genomic research and nucleic acid profiling services across Asia Pacific.
Companies are eager to make strategic moves to maintain market competition. In September 2017, Roche extended its distribution agreement with Merck to its life science brands. These include High Pure kits, transcription reagents and EagleTaq & FastStart master mixes (for non-LightCycler Systems) and Universal ProbeLibrary Probes & Assays. The following are some of the major players in global nucleic acids labeling:
PerkinElmer, Inc.
F. Hoffmann La-Roche AG
General Electric Healthcare Life Sciences
Thermo Fisher Scientific Inc.
Promega Corporation
New England Biolabs
Enzo Biochem, Inc.
Vector Laboratories Inc.
Merck KGaA
Agilent Technologies
Up Market Research published a new report titled “Nucleic Acid Labeling Market research report which is segmented by Product (Reagents, Kits), By Players/Companies Agilent Technologies, PerkinElmer Inc, Thermo Fisher Scientific Inc, Promega Corporation, Enzo Biochem Inc, Merck KGaA, F Hoffmann La-Roche AG, Vector Laboratories Inc, General Electric Healthcare Life Sciences, New England Biolabs”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.
Report Attributes | Report Details |
Report Title | Nucleic Acid Labeling Market Research Report |
By Product | Reagents, Kits |
By Companies | Agilent Technologies, PerkinElmer Inc, Thermo Fisher Scientific Inc, Promega Corporation, Enzo Biochem Inc, Merck KGaA, F Hoffmann La-Roche AG, Vector Laboratories Inc, General Electric Healthcare Life Sciences, New England Biolabs |
Regions Covered | North America, Europe, APAC, Latin America, MEA |
Base Year | 2020 |
Historical Year | 2018 to 2019 (Data from 2010 can be provided as per availability) |
Forecast Year | 2028 |
Number of Pages | 218 |
Number of Tables & Figures | 153 |
Customization Available | Yes, the report can be customized as per your need. |
The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.
The market is segmented by Product (Reagents, Kits).
Nucleic Acid Labeling Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.
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Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.
We have studied the Nucleic Acid Labeling Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.
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