Global microRNA Market by Application (Infectious Diseases, Neurological Disease, Cancer) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

Summary of the Report

Global microRNA market value was USD 854.6 million in 2020. It is expected to grow at a compound annual rate (CAGR), of 19.8% between 2021 and 2028. The market has seen major trends over the years, including emerging microRNA (miRNA), tools for disease-associated analytic applications, tremendous traction gained through miRNA target prediction, identification, and continued wide adoption of most of the miRNA instruments. MiRNAs are also among the most promising biopharmaceutical candidates for future medicines.

The market for microRNA is growing as biopharmaceutical companies become more active in searching for therapeutic molecules that could act as drugs. Many miRNA-based candidates are currently under clinical tests. These include anti-miR chemicals and specific inhibitors of miRNAs that could be used as therapeutic solutions. RNA therapeutics is a hot investment area that can lead to the development profitable drugs.

The market is growing in popularity of microRNA as biomarkers. Because they are more reliable and robust than traditional methods, the miRNA biomarkers have been a focus of genome-wide research, data-driven methodology. They are therefore promising candidates for biomarker development. The growing popularity of liquid biopsies has also led to an increase in the importance and use of miRNAs in biomarker development and discovery.

The market expansion is likely to be supported by a steady increase in research activities that examine the potential of miRNA biomarkers in prognosis, diagnosis and therapeutics. In January 2020, researchers looked into the possibility that miRNA in peripheral blood could be used as a biomarker to diagnose Bipolar II disorder (BD-II). MiRNAs could be used to diagnose other neurodegenerative diseases.

The market for microRNA is also growing due to technological innovations that improve the sensitivity of detection. Nanoparticle-based amplification is one of the new methods for miRNA detection. Other methods include DSN-based methods and LAMP-based techniques. Researchers also developed a program-based, isothermal amplification method for quantitative and specific digital measurement of miRNA in January 2020. This system has the advantage that it relies on signal amplification rather than direct replication of the targeted sequence as is the case with PCR-based approaches.

Products Insights

Consumables dominated the microRNA market and held the largest revenue share at 59.9% in 2020. There are many consumables that can be used to profile miRNAs such as detection kits and qPCR primers. Segment growth is the main reason for high consumable adoption. They are easily replaced because they are not durable. Thermo Fisher Scientific Inc., Miltenyi Biotec, and NanoString are some of the most prominent providers of consumables.

Real time PCR was the dominant market segment in 2020 with a share exceeding 32.0%. It is considered the gold standard for miRNA detection and is a preferred method to others. Because of its high sensitivity, sequence specificity and dynamic range, it is a widely used technique to detect miRNA expression. It can be used for many different applications in miRNA research, including validation, quantitation, miRNA profiling and functional analysis.

NGS is forecast to grow by 18.2% over the forecast period. Because it allows for systematic studies of the genome, and provides insight for better disease understanding, it is growing in popularity. Next generation sequencing can be integrated with many informatics tools to speed up analysis of complex miRNA sequencing data. CAP-miRSeq, for example, allows deep microRNA sequences with preprocessing, miRNA qualification and alignment. It also allows variant detection in the miRNA coding area. It allows for faster processing, easier downstream analyses, and better quality assessment.

Services Insights

The market for microRNA was dominated by services such as profiling, localization, and quantification. In 2020, they held the largest revenue share at over 35.0%. Segment growth is the main reason for increased collaboration between companies to provide microRNA profiling services. Toray approved TATAA's microRNA profiling service on the 3D Gene platform in May 2020. The 3D Gene platform for microRNA profiling has a better performance and robustness to perform and manage all workflows, including sample preparation, microRNA profiling and data analysis.

Due to increased focus on microRNA purification methods, the segment of isolation and purification is expected to experience the fastest CAGR at 16.9% during the forecast period. In November 2020, researchers created a magnetic beads-based RNA purification system that allows for the efficient analysis of small amounts of RNA, such as miRNAs. This method also allowed for real-time PCR analysis of mRNA and miRNA expression.

End-use Insights

MicroRNA was the most lucrative segment in the market and it accounted for 54.2% of the total revenue share in 2020. The growth of this segment can be attributed to government support for genomics research by research institutes and academics. In May 2020, for example, the Australian government granted a grant in the amount of USD 21.6 million to support genomics research in pediatric cancer and disease. Many grants were awarded to projects at the University of Queensland, which include whole-genome sequencing of patients with breast cancer and analysis of their genes.

Market growth is expected to be aided by the increasing importance of microRNA in diagnosing many diseases, including cancer, heart disease, and infectious diseases, via hospitals, diagnostic labs, and CROs. It is a lucrative market that will see a lot of biotechnology and pharmaceutical companies, such as Regulus Therapeutics (Mirna Therapeutics), miRagen Therapeutics, and Mirna Therapeutics, get involved in the development and commercialization of RNA-based therapeutics. These companies have produced a majority of positive results in preclinical trials and early clinical trials.

Application Insights

In 2020, the cancer segment was the dominant market for microRNA. It accounted for more than 33.0% of the total revenue. Cancer is a major pathology that involves mRNA-miRNA interaction. Many microRNA target sites are located in cancer-associated genomic areas. There are also tumor suppressor miRNAs that are often suppressed during the translation of mRNAs that encode for oncogenes, which can inhibit tumorigenesis and promote cancer development. For different cancers, microRNA dysregulation has been extensively researched.

Unprotected 5'-phosphate and 3??-hydroxy ends make miRNAs vulnerable to degradation by ribonucleases. This makes them less effective in treating cancer. Researchers are working to develop an efficient delivery system of microRNA to overcome these challenges. A nanoparticle delivery system has been developed recently to allow for targeted delivery of microRNAs. There are many nanotechnology-based formulations available, including organic-based lipid nanoparticles LNPs, naturally occurring EVs, gold, Polyamidoamine, and silica dermers.

Due to the development of molecular biomarkers that allow for early detection of cardiovascular diseases, the segment of cardiovascular disease is expected to grow at 16.1% over the forecast period. MicroRNAs are attractive targets in cardiovascular therapeutics because of their tissue-specific expression patterns, secretion to the appropriate body fluids, stability, and other advantages. Numerous studies have also shown the importance of microRNA in cardiovascular disease. It is involved in regulation of blood pressure and lipoprotein metabolism. This regulates the development of hypertension, which ultimately determines the progression of cardiovascular disease.

Regional Insights

North America was the dominant market for microRNAs (miRNAs) in 2020, accounting for 45.8% of the total revenue. This growth can be attributed to several factors, including the presence of key players and extensive R&D activities and an established research infrastructure for oncology, proteomics, and genomics. Companies in the region have also received patent approvals for miRNA biomarkers. In May 2020, DiamiR was granted U.S. Patent approval to use miRNA-based methods for monitoring and detecting brain aging. This patent covers methods for quantifying miRNA in blood plasma and brain to detect brain aging.

The fastest growing market for microRNA in Asia Pacific is 20.6% between 2021 and 2028. Rapid advancements in genomic research and the adoption new tools to support research are the main reasons for the market's growth. Researchers from China discovered blood microRNA (miRNA), which could be biomarkers for pyrrolizidine-induced hepatic sinusoidal block syndrome (HSOS) in February 2021 using microarray-based microRNA profiling. The study involved a variety of computational microRNA target tools to predict the relationship between miRNAs and their target mRNA.

Market Share Insights & Key Companies

Companies are increasing their patent portfolios for microRNA expression analysis. Sistemic Ltd, for example, announced in July 2020 that they had expanded their patent to include microRNAs as predictive analytical tools for cellular function. This patent covers microRNA expression analysis on mesenchymal stem cell samples from different donors to identify miRNAs that can be linked to cellular functions. It will also support donor screening and the development of MSC-based cell therapies. This patent grant is an addition to the company's existing patent portfolio of miRNAs for stem cell characterization, donor screening and quality control of stem cells products. It also allows for potency assay development. The market leader in microRNA (miRNA), is:

• Merck KGaA

• Thermo Fisher Scientific, Inc.

• Horizon Discovery Ltd.

• Synlogic

• QIAGEN

• GeneCopoeia, Inc.

• New England Biolabs

• Quantabio

• NanoString

• BioGenex

• SeqMatic LLC

• Miltenyi Biotec

• Sistemic Scotland Limited

• Biodynamics Laboratory Inc.

• OriGene Technologies, Inc.

Up Market Research published a new report titled “microRNA Market research report which is segmented by Application (Infectious Diseases, Neurological Disease, Cancer), By Players/Companies SeqMatic LLC, GeneCopoeia Inc, Miltenyi Biotec, Synlogic, Biodynamics Laboratory Inc, Merck KGaA, Thermo Fisher Scientific Inc, New England Biolabs, Sistemic Scotland Limited, Quantabio, OriGene Technologies Inc, QIAGEN, Horizon Discovery Ltd, BioGenex, NanoString”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.

Report Scope

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.

Global microRNA Market Report Segments:

The market is segmented by Application (Infectious Diseases, Neurological Disease, Cancer).

microRNA Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.

Key Benefits for Industry Participants & Stakeholders:

• Industry drivers, restraints, and opportunities covered in the study
• Neutral perspective on the market performance
• Recent industry trends and developments
• Competitive landscape & strategies of key players
• Potential & niche segments and regions exhibiting promising growth covered
• Historical, current, and projected market size, in terms of value
• In-depth analysis of the microRNA Market

Overview of the regional outlook of the microRNA Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.

Highlights of The microRNA Market Report:

1. The market structure and projections for the coming years.
2. Drivers, restraints, opportunities, and current trends of microRNA Market.
3. Historical data and forecast.
4. Estimations for the forecast period 2028.
5. Developments and trends in the market.

                1. Infectious Diseases

                2. Neurological Disease

                3. Cancer

7. Market scenario by region, sub-region, and country.
8. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
9. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
10. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the microRNA Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.

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Reasons to Purchase the microRNA Market Report:

• The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
• Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
• Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
• The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
• Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.