Global Hydrogel-based Drug Delivery System Market by Polymer Origin (Synthetic, Hybrid, Natural), by Route (Ocular, Subcutaneous, Oral Cavity) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

Summary of the Report

Global hydrogel-based drug delivery systems market was valued at USD 5.9 Billion in 2020. It is projected to grow at a compound annual rate (CAGR of 7.5%) between 2021 and 2028. Three-dimensional polymeric networks that can imbibe small to large drug molecules (NSAIDs, proteins, peptides) are hydrogels. They are widely used in drug delivery applications. Hydrogel is a promising drug delivery system due to its biocompatibility, biodegradability and controlled release profile. Numerous studies that evaluated the use of hydrogels in the development of COVID-19 vaccine highlight the potential future uses of hydrogel-based drug distribution systems.

High drug loading capacities combined with benefits such as controlled release, targeted delivery and targeted delivery are key factors that will drive the growth of hydrogel-based drug delivery system market. Controlled release systems allow for dose sparing, decreased side effects, lower drug administration frequency, and better patient compliance. Hydrogels are preferred drug carriers due to their ease of production and ability to be applied by themselves. The adoption rate may be hampered by the difficulty of producing hydrogels with a constant surface area.

Leading pharma companies will continue to invest in R&D and fund funding in order to develop new drugs, delivery systems and diagnostics. This is expected be one of the key factors driving the market for hydrogel-based drug distribution systems. A company's ability to create effective formulations is a key factor in its profitability. To remain competitive in the market, the pharma industry is fragmented and highly competitive. Therefore, significant investments are made in R&D. R&D activities account for approximately 15-20% of the annual revenues of pharma companies. Due to its outstanding physical properties, Hydrogel is a promising drug delivery method. Market growth is expected to be driven by the increasing R&D activity in drug delivery systems.

Pharma companies are encouraged to invest in targeted therapies because of the positive results of drug delivery system-based hydrogel clinical trials. The NBCI report, published in 2019, states that hydrogel was used in 223 clinical trials. This excludes contact lens trials. Hydrogel coil was used for diagnostic purposes in 8 clinical studies, bulk hydrogel in 166 trials and patch hydrogel in 99 clinical tests. Its market growth will be impeded by the high price of hydrogels, their low mechanical strength and compatibility with very few drugs.

Polymer Origin Insights

Hydrogel-based drug delivery systems dominated by the natural segment, which accounted for 32.3% of the total revenue share in 2020. The three main types of hydrogels can be divided by their polymer origin into synthetic, hybrid and natural. Natural hydrogels are made from proteins such as collagen, gelatin, and lysosome. They are good at adhesion but have been less popular due to their stability and mechanical issues.

The synthetic polymer hydrogel-based drug delivery systems have a higher drug absorption capacity, better mechanical properties, longer life span, and more controllable degradation. The most widely used synthetic polymers in drug delivery are Poly (vinylpyrrolidone), starch, and Poly (vinylpyrrolidone),

Hybrid hydrogels can be made from both natural and synthetic hydrogels. A new version of the SMART hydrogel is made using hybrid polymerization. Because SMART hydrogels respond to stimuli, they are more effective than conventional hydrogels. The drug release depends on chemical or physical stimuli. Targeted drug delivery with hydrogels is possible by using physical stimuli such as temperature, magnetic field, pressure, and magnetic fields. Combing natural polymers with polyacrylic acid led to the development of a PH sensitive.

Delivery Route Insights

Hydrogel-based drug delivery systems were dominated by the ocular market, which accounted for 38.5% of the total revenue in 2020. Because most contact lenses and hard lenses are made from hydrogel films, hydrogels are often used in ocular drug delivery. It is easy to include therapeutic drugs in contact lenses. Dextenza, Lacriset and Lacriset have been approved for clinical use as hydrogel-based ocular drug deliver systems. There are also ongoing clinical trials that focus on hydrogel contact lens-based drug delivery system. This is driving market growth. Massachusetts Eye and Ear Infirmary have conducted a clinical trial to test the delivery of dexamethasone through the hydrogel lens.

Over the forecast period, the subcutaneous drug delivery market is expected to see a 9.3% CAGR in hydrogel-based drug administration systems. Because hydrogel is a biodegradable material, it is widely used in subcutaneous drug delivery systems. Implants can be removed surgically because they naturally degrade within the body. Recent developments in subcutaneous hydrogel implants allow for controlled release of anticancer drug. A subcutaneous hydrogel implant, for example, was created by cross-linking the anticancer drug Cytarabine with poly (2-hydroxyethylmethacrylate) hydrogel. Endo pharmaceutical has developed Supprelin, a hydrogel-based subcutaneous implant which allows controlled release of histrelin.

Hydrogels can be infused with drugs to treat local conditions in the buccal cavity, such as periodontal disease and oral cancer. Hydrogel's excellent adhesion properties and retention properties with the oral cavity mucosa allow for local drug delivery. A hydrogel-based drug delivery method is used to deliver drugs into the oral cavity. The other segments of drug delivery routes that are expected to grow in the future include Vaginal, Transdermal and Rectal.

Regional Insights

North America was the dominant market for hydrogel-based drug delivery system systems in 2020, accounting for 46.1% of the total revenue. Market growth is expected to be driven by the availability of effective reimbursement to cover the cost of modern therapies, as well as the presence of hydrogel suppliers in the region. Dare Bioscience, an American biopharmaceutical company, announced positive results in clinical trials that were conducted to access drugs (clindamycinphosphate 2%) via bioadhesive gel. In the United States, bacterial vaginosis affects more than 20 million people.

Market growth will be driven by increasing market research, the increasing prevalence of CNS disorders and funding for hydrogel-based drug delivery system. The European Union announced funding in 2021 for 13 projects, including the development of a hydrogel-based hyaluronan-based system in mucosal drug administration. The project is expected to begin in October 2021 and continue for a period three years. These initiatives will bring new hydrogel-based drug delivery methods, which is expected to propel the market growth.

Asia Pacific is expected to see the fastest growth in the market for drug delivery systems using hydrogels. Market growth is expected to be driven by the following factors: a large target market, improved access to healthcare, rising demand for better medical care in many therapeutic fields, and rising healthcare costs. China, India, South Korea, and Brazil are just a few markets that have shown lucrative growth rates.

Market Share and Key Companies

It is common to see key companies engaging in market expansion activities to increase sales and profit. Ferring B.V. was granted approval by the Japanese Minister of Health, Labor and Welfare (MHLW), January 2020, to market their hydrogel-based drug delivery system for cervical ripening. The approval will likely boost the company's revenue as Japan is a highly lucrative market for women’s health and well-being.

To survive in a highly competitive market, market players adopt strategies like partnership, acquisitions, mergers, joint ventures, and product launches. Ocular Therapeutix, Inc., for instance, has created a hydrogel-ocular implant that delivers tyrosinekinase inhibitors in controlled ways. In 2018, the product was accepted into the first phase of a clinical trial. The market leader in hydrogel-based drug delivery systems is:

• GALDERMA

• Blairex Laboratories, Inc.

• Johnson & Johnson

• Bausch and Lomb

• Medtronic

• Ocular Therapeutix, Inc.

• Ferring B.V.

• Endo International plc

• Akorn, Incorporated

• Tolmar Pharmaceuticals, Inc.

Up Market Research published a new report titled “Hydrogel-based Drug Delivery System Market research report which is segmented by Polymer Origin (Synthetic, Hybrid, Natural), by Route (Ocular, Subcutaneous, Oral Cavity), By Players/Companies Akorn Incorporated, Johnson & Johnson, Medtronic, Tolmar Pharmaceuticals Inc, Ocular Therapeutix Inc, Bausch and Lomb, Ferring BV, Endo International plc, GALDERMA, Blairex Laboratories Inc”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.

Report Scope

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.

Global Hydrogel-based Drug Delivery System Market Report Segments:

The market is segmented by Polymer Origin (Synthetic, Hybrid, Natural), by Route (Ocular, Subcutaneous, Oral Cavity).

Hydrogel-based Drug Delivery System Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.

Key Benefits for Industry Participants & Stakeholders:

• Industry drivers, restraints, and opportunities covered in the study
• Neutral perspective on the market performance
• Recent industry trends and developments
• Competitive landscape & strategies of key players
• Potential & niche segments and regions exhibiting promising growth covered
• Historical, current, and projected market size, in terms of value
• In-depth analysis of the Hydrogel-based Drug Delivery System Market

Overview of the regional outlook of the Hydrogel-based Drug Delivery System Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.

Highlights of The Hydrogel-based Drug Delivery System Market Report:

1. The market structure and projections for the coming years.
2. Drivers, restraints, opportunities, and current trends of Hydrogel-based Drug Delivery System Market.
3. Historical data and forecast.
4. Estimations for the forecast period 2028.
5. Developments and trends in the market.

                1. Synthetic

                2. Hybrid

                3. Natural

                1. Ocular

                2. Subcutaneous

                3. Oral Cavity

8. Market scenario by region, sub-region, and country.
9. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
10. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
11. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the Hydrogel-based Drug Delivery System Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.

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Reasons to Purchase the Hydrogel-based Drug Delivery System Market Report:

• The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
• Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
• Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
• The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
• Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.