Global downstream processing market was valued at USD 21.4 million in 2020. It is projected to grow at a compound annual rate (CAGR of 15.9%) between 2021 and 2028. The market is being driven by a rise in downstream processing methods for the development COVID-19 vaccines. Rentschler Biopharma, a German contract development and manufacturing organisation (CDMO), announced in February 2021 that it would begin commercial production, formulation and downstream processing for CVnCoV COVID-19 candidate vaccination by CureVac. Bayer announced that it will produce 160 million doses CVnCoV vaccines in 2022.
Thermo Fisher Scientific announced in January 2021 that it would support 250 COVID-19 treatment projects as well as vaccine production in 2020. These projects are supported by Thermo Fisher Scientific's CDMO capabilities, as well as its range of bioprocess consumables. To expand its capabilities in vaccine and therapy development, it has partnered with Singapore as well as the U.S. government. EMD Millipore and Cytiva have also made similar efforts to make use of their bioprocess offerings in COVID-19 therapeutics research.
The adoption of continuous downstream processing systems has led to an increase in R&D activities in advanced bioprocess technology. These systems can be used for multicomponent separations and perfusion chromatography systems. This has resulted in a rise in the demand for improved bioprocessing technologies to address the purification bottleneck.
CMOs are increasingly being used for downstream processing. This is because outsourcing allows pharmaceutical companies to reduce their initial capital investment and costs. CMOs assist drug manufacturers in optimizing downstream processing, as well as other processes like cell culture preparation, chromatography and mixing, concentration, monitoring, and disposable technologies.
In 2020, the market for downstream processing was dominated by the chromatography system segment which accounted for 40.6% of the highest revenue share. The segment's growth is expected to be driven by continuous R&D to improve efficiency and speed. Bolt Biotherapeutics performed chromatography modeling with GoSilico ChromX simulation software in December 2020 to speed up bioprocessing.
Segment growth is also supported by a rise in deals and developments related to chromatography systems. In January 2021 Sartorius Stedim Biotech made an announcement to purchase Novasep's chromatography equipment business. Sartorius will be able to create novel chromatography systems that will solve efficiency problems and bottlenecks in downstream processes.
From 2021 to 2028, the segment filters is expected to experience the highest CAGR. This market is driven by the increasing use of filters for viral activation. A team of researchers from Pennsylvania State University examined the effectiveness of BioEX hollow fibre and Planova 20N virus filter for the removal viral-size particles. These studies will likely increase the adoption of filters for downstream processing biologics.
Due to multiple uses of antibiotics in the treatment of many disorders, the Production segment dominated downstream processing. It generated 32.9% of the total revenue share for 2020. Annually, more than 700,000. people are affected by antibiotic-resistant bacteria. This results in a high demand for antibiotics, which drives market growth.
The rise in demand monoclonal antibody drove the fastest growth in antibodies production. Segment growth is also driven by the launch of new products that allow for efficient purification. Cytiva, for example, launched HiScreen Fibro PrismA in January 2021 to develop and purify monoclonal antibodies (mAb) through process development. This product is a fiber-based Protein A platform that allows for a 20-fold increase of productivity.
Purification by chromatography was the dominant segment of downstream processing and held the largest revenue share at 40.9% in 2020. Companies are pursuing business development strategies, such as acquisitions, mergers, and agreements to expand their chromatography portfolio.
Repligen Corporation, for example, entered into a definitive agreement in October 2020 to acquire ARTeSYN Biosolutions. ARTeSYN Biosolutions has a long history of providing single-use filtration systems and chromatography systems. A wide range of single-use systems are available for continuous manufacturing and buffer preparation.
Similar to the acquisition of Danaher Corporation's chromatography equipment and resins as well as particle validation standards, microcarriers and microcarriers in April 2020 by Sartorius AG, Sartorius AG also acquired single-use tangential flow filter business and chromatography hardware. The acquisition will allow the company to increase its downstream processing options for chromatography system.
The highest expected CAGR for solid-liquid separation will be 16.9% over the forecast period. Solid-liquid separation has many advantages, including its simplicity, cost-effectiveness, and suitability for continuous mode manufacturing. This technique can be hindered by the high shear forces. For high cell density processes, it is increasingly being used depth filters, which include multistage depth filter, alternating tangential microfiltration, and depth filters.
North America was the dominant market for downstream processing, with a 34.6% revenue share in 2020. This is due to the government's support for bioprocess technologies, growing medical expenditure and a developed healthcare infrastructure. The region has also seen major collaborations with large healthcare companies that invest heavily in R&D for biopharmaceuticals, vaccines and other related products.
Key players in the downstream processing market are also expanding their presence in this region. Thermo Fisher Scientific Inc., for the commercial production of medicines, vaccines and therapies, announced expansion plans in North America and Europe in December 2020. This expansion included 15 commercial development and cGMP production lines. It leveraged the company's strong quality standards to support a wide range of manufacturing capabilities.
Due to rising investment by both consumers and developers in biotechnology, Asia Pacific's downstream processing market is expected to grow at 17.3%. A large population base drives the demand for advanced medical facilities. Players are keen to implement rapid analytical methods to support bioprocess design and bioprocessing.
China held the largest market share in Asia Pacific due to its growing biopharmaceutical sector and increased demand for vaccines and medicines. China's biopharmaceutical sector is one of the most dynamic economic sectors. It is also marked by continuous innovation with new biopharmaceutical equipment.
Companies are also entering into strategic partnerships to promote vaccine and drug development in China. In November 2020, Cytiva signed deals with Wego, Jinbofor and Clover to increase investment in manufacturing and bioprocess development. It offers a broad range of products including bioprocess filtration and chromatography products as well as cell culture and fermentation processes.
Companies are increasingly focused on developing new products for downstream processing. Corning Incorporated, for instance, launched the Corning XSERIES cell processing platform in June 2020. The X-SERIES products include the X-LAB System and X-WASH System and the X-MINI Selection Kit to facilitate cell separation and purification. The XSERIES cell processing platform has applications in immuno cell therapy, bioprocess medicine and gene therapy fields. This allowed the company to expand its market share. The following are some of the most prominent players in downstream processing:
Merck KGaA
Sartorius Stedim Biotech S.A
GE Healthcare
Thermo Fisher Scientific Inc.
Danaher Corporation
Repligen
3M Company
Boehringer Ingelheim International GmbH
Corning Corporation
Lonza Group Ltd
Dover Corporation
Ashai Kasei
Ferner PLC
Eppendorf AG
Up Market Research published a new report titled “Downstream Processing Market research report which is segmented by Product (Filters, Chromatography Systems), by Technique (Purification, Formulation), By Players/Companies Sartorius Stedim Biotech SA, Eppendorf AG, Ashai Kasei, Ferner PLC, Danaher Corporation, Boehringer Ingelheim International GmbH, 3M Company, Corning Corporation, Repligen, Dover Corporation, Thermo Fisher Scientific Inc, Lonza Group Ltd, GE Healthcare, Merck KGaA”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.
Report Attributes | Report Details |
Report Title | Downstream Processing Market Research Report |
By Product | Filters, Chromatography Systems |
By Technique | Purification, Formulation |
By Companies | Sartorius Stedim Biotech SA, Eppendorf AG, Ashai Kasei, Ferner PLC, Danaher Corporation, Boehringer Ingelheim International GmbH, 3M Company, Corning Corporation, Repligen, Dover Corporation, Thermo Fisher Scientific Inc, Lonza Group Ltd, GE Healthcare, Merck KGaA |
Regions Covered | North America, Europe, APAC, Latin America, MEA |
Base Year | 2020 |
Historical Year | 2018 to 2019 (Data from 2010 can be provided as per availability) |
Forecast Year | 2028 |
Number of Pages | 207 |
Number of Tables & Figures | 145 |
Customization Available | Yes, the report can be customized as per your need. |
The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.
The market is segmented by Product (Filters, Chromatography Systems), by Technique (Purification, Formulation).
Downstream Processing Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.
Key Benefits for Industry Participants & Stakeholders:
Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.
We have studied the Downstream Processing Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.
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