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Global Downstream Processing Market by Product (Filters, Chromatography Systems), by Technique (Purification, Formulation) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

  • Report ID: NT-73227
  • Author: Up Market Research
  • Rating: 5.0
  • Total Reviews: 76
  • No. Of Pages: 207
  • Format:
  • Pub. Date: 2021-10-21
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Summary of the Report

Global downstream processing market was valued at USD 21.4 million in 2020. It is projected to grow at a compound annual rate (CAGR of 15.9%) between 2021 and 2028. The market is being driven by a rise in downstream processing methods for the development COVID-19 vaccines. Rentschler Biopharma, a German contract development and manufacturing organisation (CDMO), announced in February 2021 that it would begin commercial production, formulation and downstream processing for CVnCoV COVID-19 candidate vaccination by CureVac. Bayer announced that it will produce 160 million doses CVnCoV vaccines in 2022.

Thermo Fisher Scientific announced in January 2021 that it would support 250 COVID-19 treatment projects as well as vaccine production in 2020. These projects are supported by Thermo Fisher Scientific's CDMO capabilities, as well as its range of bioprocess consumables. To expand its capabilities in vaccine and therapy development, it has partnered with Singapore as well as the U.S. government. EMD Millipore and Cytiva have also made similar efforts to make use of their bioprocess offerings in COVID-19 therapeutics research.

The adoption of continuous downstream processing systems has led to an increase in R&D activities in advanced bioprocess technology. These systems can be used for multicomponent separations and perfusion chromatography systems. This has resulted in a rise in the demand for improved bioprocessing technologies to address the purification bottleneck.

CMOs are increasingly being used for downstream processing. This is because outsourcing allows pharmaceutical companies to reduce their initial capital investment and costs. CMOs assist drug manufacturers in optimizing downstream processing, as well as other processes like cell culture preparation, chromatography and mixing, concentration, monitoring, and disposable technologies.

Products Insights

In 2020, the market for downstream processing was dominated by the chromatography system segment which accounted for 40.6% of the highest revenue share. The segment's growth is expected to be driven by continuous R&D to improve efficiency and speed. Bolt Biotherapeutics performed chromatography modeling with GoSilico ChromX simulation software in December 2020 to speed up bioprocessing.

Segment growth is also supported by a rise in deals and developments related to chromatography systems. In January 2021 Sartorius Stedim Biotech made an announcement to purchase Novasep's chromatography equipment business. Sartorius will be able to create novel chromatography systems that will solve efficiency problems and bottlenecks in downstream processes.

From 2021 to 2028, the segment filters is expected to experience the highest CAGR. This market is driven by the increasing use of filters for viral activation. A team of researchers from Pennsylvania State University examined the effectiveness of BioEX hollow fibre and Planova 20N virus filter for the removal viral-size particles. These studies will likely increase the adoption of filters for downstream processing biologics.

Application Insights

Due to multiple uses of antibiotics in the treatment of many disorders, the Production segment dominated downstream processing. It generated 32.9% of the total revenue share for 2020. Annually, more than 700,000. people are affected by antibiotic-resistant bacteria. This results in a high demand for antibiotics, which drives market growth.

The rise in demand monoclonal antibody drove the fastest growth in antibodies production. Segment growth is also driven by the launch of new products that allow for efficient purification. Cytiva, for example, launched HiScreen Fibro PrismA in January 2021 to develop and purify monoclonal antibodies (mAb) through process development. This product is a fiber-based Protein A platform that allows for a 20-fold increase of productivity.

Technique Insights

Purification by chromatography was the dominant segment of downstream processing and held the largest revenue share at 40.9% in 2020. Companies are pursuing business development strategies, such as acquisitions, mergers, and agreements to expand their chromatography portfolio.

Repligen Corporation, for example, entered into a definitive agreement in October 2020 to acquire ARTeSYN Biosolutions. ARTeSYN Biosolutions has a long history of providing single-use filtration systems and chromatography systems. A wide range of single-use systems are available for continuous manufacturing and buffer preparation.

Similar to the acquisition of Danaher Corporation's chromatography equipment and resins as well as particle validation standards, microcarriers and microcarriers in April 2020 by Sartorius AG, Sartorius AG also acquired single-use tangential flow filter business and chromatography hardware. The acquisition will allow the company to increase its downstream processing options for chromatography system.

The highest expected CAGR for solid-liquid separation will be 16.9% over the forecast period. Solid-liquid separation has many advantages, including its simplicity, cost-effectiveness, and suitability for continuous mode manufacturing. This technique can be hindered by the high shear forces. For high cell density processes, it is increasingly being used depth filters, which include multistage depth filter, alternating tangential microfiltration, and depth filters.

Regional Insights

North America was the dominant market for downstream processing, with a 34.6% revenue share in 2020. This is due to the government's support for bioprocess technologies, growing medical expenditure and a developed healthcare infrastructure. The region has also seen major collaborations with large healthcare companies that invest heavily in R&D for biopharmaceuticals, vaccines and other related products.

Key players in the downstream processing market are also expanding their presence in this region. Thermo Fisher Scientific Inc., for the commercial production of medicines, vaccines and therapies, announced expansion plans in North America and Europe in December 2020. This expansion included 15 commercial development and cGMP production lines. It leveraged the company's strong quality standards to support a wide range of manufacturing capabilities.

Due to rising investment by both consumers and developers in biotechnology, Asia Pacific's downstream processing market is expected to grow at 17.3%. A large population base drives the demand for advanced medical facilities. Players are keen to implement rapid analytical methods to support bioprocess design and bioprocessing.

China held the largest market share in Asia Pacific due to its growing biopharmaceutical sector and increased demand for vaccines and medicines. China's biopharmaceutical sector is one of the most dynamic economic sectors. It is also marked by continuous innovation with new biopharmaceutical equipment.

Companies are also entering into strategic partnerships to promote vaccine and drug development in China. In November 2020, Cytiva signed deals with Wego, Jinbofor and Clover to increase investment in manufacturing and bioprocess development. It offers a broad range of products including bioprocess filtration and chromatography products as well as cell culture and fermentation processes.

Market Share Insights & Key Companies

Companies are increasingly focused on developing new products for downstream processing. Corning Incorporated, for instance, launched the Corning XSERIES cell processing platform in June 2020. The X-SERIES products include the X-LAB System and X-WASH System and the X-MINI Selection Kit to facilitate cell separation and purification. The XSERIES cell processing platform has applications in immuno cell therapy, bioprocess medicine and gene therapy fields. This allowed the company to expand its market share. The following are some of the most prominent players in downstream processing:

  • Merck KGaA

  • Sartorius Stedim Biotech S.A

  • GE Healthcare

  • Thermo Fisher Scientific Inc.

  • Danaher Corporation

  • Repligen

  • 3M Company

  • Boehringer Ingelheim International GmbH

  • Corning Corporation

  • Lonza Group Ltd

  • Dover Corporation

  • Ashai Kasei

  • Ferner PLC

  • Eppendorf AG

Up Market Research published a new report titled “Downstream Processing Market research report which is segmented by Product (Filters, Chromatography Systems), by Technique (Purification, Formulation), By Players/Companies Sartorius Stedim Biotech SA, Eppendorf AG, Ashai Kasei, Ferner PLC, Danaher Corporation, Boehringer Ingelheim International GmbH, 3M Company, Corning Corporation, Repligen, Dover Corporation, Thermo Fisher Scientific Inc, Lonza Group Ltd, GE Healthcare, Merck KGaA”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.


Report Scope

Report AttributesReport Details
Report TitleDownstream Processing Market Research Report
By ProductFilters, Chromatography Systems
By TechniquePurification, Formulation
By CompaniesSartorius Stedim Biotech SA, Eppendorf AG, Ashai Kasei, Ferner PLC, Danaher Corporation, Boehringer Ingelheim International GmbH, 3M Company, Corning Corporation, Repligen, Dover Corporation, Thermo Fisher Scientific Inc, Lonza Group Ltd, GE Healthcare, Merck KGaA
Regions CoveredNorth America, Europe, APAC, Latin America, MEA
Base Year2020
Historical Year2018 to 2019 (Data from 2010 can be provided as per availability)
Forecast Year2028
Number of Pages207
Number of Tables & Figures145
Customization AvailableYes, the report can be customized as per your need.

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.


Global Downstream Processing Industry Outlook

Global Downstream Processing Market Report Segments:

The market is segmented by Product (Filters, Chromatography Systems), by Technique (Purification, Formulation).

Downstream Processing Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.


Key Benefits for Industry Participants & Stakeholders:

  • Industry drivers, restraints, and opportunities covered in the study
  • Neutral perspective on the market performance
  • Recent industry trends and developments
  • Competitive landscape & strategies of key players
  • Potential & niche segments and regions exhibiting promising growth covered
  • Historical, current, and projected market size, in terms of value
  • In-depth analysis of the Downstream Processing Market

Overview of the regional outlook of the Downstream Processing Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.


Downstream Processing Market Overview

Highlights of The Downstream Processing Market Report:

  1. The market structure and projections for the coming years.
  2. Drivers, restraints, opportunities, and current trends of Downstream Processing Market.
  3. Historical data and forecast.
  4. Estimations for the forecast period 2028.
  5. Developments and trends in the market.
        6. By Product:

                1. Filters

                2. Chromatography Systems

        7. By Technique:

                1. Purification

                2. Formulation

  1. Market scenario by region, sub-region, and country.
  2. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
  3. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
  4. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the Downstream Processing Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.


How you may use our products:

  • Correctly Positioning New Products
  • Market Entry Strategies
  • Business Expansion Strategies
  • Consumer Insights
  • Understanding Competition Scenario
  • Product & Brand Management
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Downstream Processing Market Trends

Reasons to Purchase the Downstream Processing Market Report:

  • The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
  • Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
  • Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
  • The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
  • Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.
Chapter 1 Executive Summary
Chapter 2 Assumptions and Acronyms Used
Chapter 3 Research Methodology
Chapter 4 Downstream Processing Market Overview
   4.1 Introduction 
      4.1.1 Market Taxonomy 
      4.1.2 Market Definition 
      4.1.3 Macro-Economic Factors Impacting the Market Growth 
   4.2 Downstream Processing Market Dynamics 
      4.2.1 Market Drivers 
      4.2.2 Market Restraints 
      4.2.3 Market Opportunity 
   4.3 Downstream Processing Market - Supply Chain Analysis 
      4.3.1 List of Key Suppliers 
      4.3.2 List of Key Distributors 
      4.3.3 List of Key Consumers 
   4.4 Key Forces Shaping the Downstream Processing Market 
      4.4.1 Bargaining Power of Suppliers 
      4.4.2 Bargaining Power of Buyers 
      4.4.3 Threat of Substitution 
      4.4.4 Threat of New Entrants 
      4.4.5 Competitive Rivalry 
   4.5 Global Downstream Processing Market Size & Forecast, 2018-2028 
      4.5.1 Downstream Processing Market Size and Y-o-Y Growth 
      4.5.2 Downstream Processing Market Absolute $ Opportunity 


Chapter 5 Global Downstream Processing Market Analysis and Forecast by Product
   5.1 Introduction
      5.1.1 Key Market Trends & Growth Opportunities by Product
      5.1.2 Basis Point Share (BPS) Analysis by Product
      5.1.3 Absolute $ Opportunity Assessment by Product
   5.2 Downstream Processing Market Size Forecast by Product
      5.2.1 Filters
      5.2.2 Chromatography Systems
   5.3 Market Attractiveness Analysis by Product

Chapter 6 Global Downstream Processing Market Analysis and Forecast by Technique
   6.1 Introduction
      6.1.1 Key Market Trends & Growth Opportunities by Technique
      6.1.2 Basis Point Share (BPS) Analysis by Technique
      6.1.3 Absolute $ Opportunity Assessment by Technique
   6.2 Downstream Processing Market Size Forecast by Technique
      6.2.1 Purification
      6.2.2 Formulation
   6.3 Market Attractiveness Analysis by Technique

Chapter 7 Global Downstream Processing Market Analysis and Forecast by Region
   7.1 Introduction
      7.1.1 Key Market Trends & Growth Opportunities by Region
      7.1.2 Basis Point Share (BPS) Analysis by Region
      7.1.3 Absolute $ Opportunity Assessment by Region
   7.2 Downstream Processing Market Size Forecast by Region
      7.2.1 North America
      7.2.2 Europe
      7.2.3 Asia Pacific
      7.2.4 Latin America
      7.2.5 Middle East & Africa (MEA)
   7.3 Market Attractiveness Analysis by Region

Chapter 8 Coronavirus Disease (COVID-19) Impact 
   8.1 Introduction 
   8.2 Current & Future Impact Analysis 
   8.3 Economic Impact Analysis 
   8.4 Government Policies 
   8.5 Investment Scenario

Chapter 9 North America Downstream Processing Analysis and Forecast
   9.1 Introduction
   9.2 North America Downstream Processing Market Size Forecast by Country
      9.2.1 U.S.
      9.2.2 Canada
   9.3 Basis Point Share (BPS) Analysis by Country
   9.4 Absolute $ Opportunity Assessment by Country
   9.5 Market Attractiveness Analysis by Country
   9.6 North America Downstream Processing Market Size Forecast by Product
      9.6.1 Filters
      9.6.2 Chromatography Systems
   9.7 Basis Point Share (BPS) Analysis by Product 
   9.8 Absolute $ Opportunity Assessment by Product 
   9.9 Market Attractiveness Analysis by Product
   9.10 North America Downstream Processing Market Size Forecast by Technique
      9.10.1 Purification
      9.10.2 Formulation
   9.11 Basis Point Share (BPS) Analysis by Technique 
   9.12 Absolute $ Opportunity Assessment by Technique 
   9.13 Market Attractiveness Analysis by Technique

Chapter 10 Europe Downstream Processing Analysis and Forecast
   10.1 Introduction
   10.2 Europe Downstream Processing Market Size Forecast by Country
      10.2.1 Germany
      10.2.2 France
      10.2.3 Italy
      10.2.4 U.K.
      10.2.5 Spain
      10.2.6 Russia
      10.2.7 Rest of Europe
   10.3 Basis Point Share (BPS) Analysis by Country
   10.4 Absolute $ Opportunity Assessment by Country
   10.5 Market Attractiveness Analysis by Country
   10.6 Europe Downstream Processing Market Size Forecast by Product
      10.6.1 Filters
      10.6.2 Chromatography Systems
   10.7 Basis Point Share (BPS) Analysis by Product 
   10.8 Absolute $ Opportunity Assessment by Product 
   10.9 Market Attractiveness Analysis by Product
   10.10 Europe Downstream Processing Market Size Forecast by Technique
      10.10.1 Purification
      10.10.2 Formulation
   10.11 Basis Point Share (BPS) Analysis by Technique 
   10.12 Absolute $ Opportunity Assessment by Technique 
   10.13 Market Attractiveness Analysis by Technique

Chapter 11 Asia Pacific Downstream Processing Analysis and Forecast
   11.1 Introduction
   11.2 Asia Pacific Downstream Processing Market Size Forecast by Country
      11.2.1 China
      11.2.2 Japan
      11.2.3 South Korea
      11.2.4 India
      11.2.5 Australia
      11.2.6 South East Asia (SEA)
      11.2.7 Rest of Asia Pacific (APAC)
   11.3 Basis Point Share (BPS) Analysis by Country
   11.4 Absolute $ Opportunity Assessment by Country
   11.5 Market Attractiveness Analysis by Country
   11.6 Asia Pacific Downstream Processing Market Size Forecast by Product
      11.6.1 Filters
      11.6.2 Chromatography Systems
   11.7 Basis Point Share (BPS) Analysis by Product 
   11.8 Absolute $ Opportunity Assessment by Product 
   11.9 Market Attractiveness Analysis by Product
   11.10 Asia Pacific Downstream Processing Market Size Forecast by Technique
      11.10.1 Purification
      11.10.2 Formulation
   11.11 Basis Point Share (BPS) Analysis by Technique 
   11.12 Absolute $ Opportunity Assessment by Technique 
   11.13 Market Attractiveness Analysis by Technique

Chapter 12 Latin America Downstream Processing Analysis and Forecast
   12.1 Introduction
   12.2 Latin America Downstream Processing Market Size Forecast by Country
      12.2.1 Brazil
      12.2.2 Mexico
      12.2.3 Rest of Latin America (LATAM)
   12.3 Basis Point Share (BPS) Analysis by Country
   12.4 Absolute $ Opportunity Assessment by Country
   12.5 Market Attractiveness Analysis by Country
   12.6 Latin America Downstream Processing Market Size Forecast by Product
      12.6.1 Filters
      12.6.2 Chromatography Systems
   12.7 Basis Point Share (BPS) Analysis by Product 
   12.8 Absolute $ Opportunity Assessment by Product 
   12.9 Market Attractiveness Analysis by Product
   12.10 Latin America Downstream Processing Market Size Forecast by Technique
      12.10.1 Purification
      12.10.2 Formulation
   12.11 Basis Point Share (BPS) Analysis by Technique 
   12.12 Absolute $ Opportunity Assessment by Technique 
   12.13 Market Attractiveness Analysis by Technique

Chapter 13 Middle East & Africa (MEA) Downstream Processing Analysis and Forecast
   13.1 Introduction
   13.2 Middle East & Africa (MEA) Downstream Processing Market Size Forecast by Country
      13.2.1 Saudi Arabia
      13.2.2 South Africa
      13.2.3 UAE
      13.2.4 Rest of Middle East & Africa (MEA)
   13.3 Basis Point Share (BPS) Analysis by Country
   13.4 Absolute $ Opportunity Assessment by Country
   13.5 Market Attractiveness Analysis by Country
   13.6 Middle East & Africa (MEA) Downstream Processing Market Size Forecast by Product
      13.6.1 Filters
      13.6.2 Chromatography Systems
   13.7 Basis Point Share (BPS) Analysis by Product 
   13.8 Absolute $ Opportunity Assessment by Product 
   13.9 Market Attractiveness Analysis by Product
   13.10 Middle East & Africa (MEA) Downstream Processing Market Size Forecast by Technique
      13.10.1 Purification
      13.10.2 Formulation
   13.11 Basis Point Share (BPS) Analysis by Technique 
   13.12 Absolute $ Opportunity Assessment by Technique 
   13.13 Market Attractiveness Analysis by Technique

Chapter 14 Competition Landscape 
   14.1 Downstream Processing Market: Competitive Dashboard
   14.2 Global Downstream Processing Market: Market Share Analysis, 2019
   14.3 Company Profiles (Details – Overview, Financials, Developments, Strategy) 
      14.3.1 Sartorius Stedim Biotech SA
      14.3.2 Eppendorf AG
      14.3.3 Ashai Kasei
      14.3.4 Ferner PLC
      14.3.5 Danaher Corporation
      14.3.6 Boehringer Ingelheim International GmbH
      14.3.7 3M Company
      14.3.8 Corning Corporation
      14.3.9 Repligen
      14.3.10 Dover Corporation
      14.3.11 Thermo Fisher Scientific Inc
      14.3.12 Lonza Group Ltd
      14.3.13 GE Healthcare
      14.3.14 Merck KGaA
Segments Covered in the Report
The global Downstream Processing market has been segmented based on

By Product
  • Filters
  • Chromatography Systems
By Technique
  • Purification
  • Formulation
Regions
  • Asia Pacific
  • North America
  • Latin America
  • Europe
  • Middle East & Africa
Key Players
  • Sartorius Stedim Biotech SA
  • Eppendorf AG
  • Ashai Kasei
  • Ferner PLC
  • Danaher Corporation
  • Boehringer Ingelheim International GmbH
  • 3M Company
  • Corning Corporation
  • Repligen
  • Dover Corporation
  • Thermo Fisher Scientific Inc
  • Lonza Group Ltd
  • GE Healthcare
  • Merck KGaA

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