Global Cell Expansion Market by Product (Consumables, Instruments), by Cell Type (Animal, Mammalian) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

Summary of the Report

Global cell expansion market was valued at USD 19.2 Billion in 2019. It is forecast to grow at a compound annual rate (CAGR), of 9.4% during the forecast period. One of the key market drivers is the increased use of automated solutions for cell expansion applications. Automated systems reduce the cost and manpower required to produce Cell Therapy Products (CTP), Gene Therapies, as well as other biologics. This results in robust and reliable processes.

To meet the growing demand for CTP products, key players in CTP development are expanding the product lines. Lonza, for example, introduced a complete portfolio of CellBio Services in March 2019. This includes banking and cell-line expansion. This solution was created to meet research application requirements and accelerate the market's revenue generation.

CTP manufacturing has significant advantages due to the paradigm shift towards Single-Use Systems. SUS eliminates the risk of culture contamination and cross-contamination caused by improper sterilization. SUS allows for the production of CTP at high cell counts and offers long-term cost savings. SUS adoption increases the production of CTP and boosts market growth.

The life sciences industry is seeing a rise in popularity for cellular therapies. The market is driven by the increase in funding from government and private organizations, as well as initiatives taken by them to promote the development of cellular therapies. The International Society for Stem Cell Research participates in the identification and evaluation of related funding opportunities for biomedical research applications.

CTP manufacturing requires the substitution of serum and incompatible reagents in order to maintain product quality. Numerous research studies have shown that serum-free media can improve product quality. A platform for optimizing serum-free cultures has been developed by researchers. It combines high-throughput tools and a differential evolution-based algorithm. This allows for an automated, effective optimization strategy.

Product Insights

Consumables accounted for 46.8% overall of the product segment's share in 2019. It is expected to maintain its dominant position in the future. This segment has a large revenue share due to its wide variety of commercial media and reagents that cater to specific types of cells. These products can also be used in convenient and ready-to use forms.

Automation in bioreactors, and other expansion platforms that improve the efficiency of culturing processes, is expected to drive the instruments segment to the highest CAGR. Automated platforms have made it easier to standardize the process, facilitate process tracking and reduce hands-on time. This allows skilled personnel to make more efficient use of their time.

The instruments segment also generates revenue through continuous commercialization and the introduction of automated culturing devices. Hitachi, Ltd., for example, introduced automated cell mass cultivation equipment in Japan in March 2019. This allowed the production of induced pluripotent cells for regenerative medicine. These efforts will help to increase the revenue generated for instruments.

Cell Type Insights

The largest revenue share was held by mammalian cells at 58.5% in 2019. This segment will continue to dominate the forecast period because these culture systems are highly preferable in the production of complex proteins therapeutics. These systems are functionally and pharmacokinetically relevant to post-translational changes in humans. These systems are used to produce most biopharmaceuticals including monoclonal antibodies, specific interferons and thrombolytics as well as other therapeutic enzymes.

Because these cells have a specific function within the body, differentiated human cells made up a significant revenue share. Differentiated cells such as fibroblasts have been a major contributor to skin bioengineering and cutaneous wound healing. This has helped increase the growth of segments. The use of 3D Gingival Fibroblasts (GF) as an in vitro biomaterial test has increased their popularity.

Stem cells from human beings have been gaining significant attention and will see the highest CAGR between 2020-2027. This is due to the rapid growth in research in this area and the success of regenerative medicine. The segment is driven by the implementation of automated, robotic and closed production systems for the production of clinical-grade mesenchymal cells.

Application Insights

Due to the increase in approvals of biopharmaceutical product in recent years, the biopharmaceutical sector accounted for 22.9% of the total revenue in 2019. Biopharmaceutical development is further fueled by the entry of new companies and the proliferation of bioprocessing technology. This in turn boosts bio-production expansion.

Single-use technologies are also gaining traction in the commercialization of cellular therapies. Over the years, we have seen the introduction of other planar cell expansion technologies such as compact multilayer bioreactors. This has allowed for the development of closed systems that limit contamination risks and keep control over large-scale production.

Due to the rapid expansion of cell-based vaccine manufacturing in recent years, the vaccine production segment will experience the highest growth rate over the forecast period. These vaccines can be produced at a lower cost and speed up the development process.

End-use Insights

The largest segment, biotechnology and biopharmaceutical businesses, held 48% of the market share in 2019. This number will continue to grow at a rapid pace. One of the main factors behind the high share of biopharmaceutical businesses is the expanding horizon of cell-based therapies in the healthcare sector. Cell-based therapies are gaining popularity in Regenerative medicine and with continuous improvements in injectable cells delivery systems for different clinical applications.

Pharmaceutical and biopharmaceutical companies also engage in acquisitions to increase their product range. In December 2019, Sartorius AG entered into an agreement to purchase 50% of Biological Industries, an Israeli manufacturer of cell culture media. This acquisition enriched Sartorius' cell culture media portfolio, particularly for advanced therapies such as cellular and gene therapies and regenerative medicine.

The fastest CAGR is expected to be recorded by research institutes between 2020 and 2027, as they are involved in multiple studies in the biomedical area. In April 2019, for example, researchers at the University of Wisconsin in the U.S. introduced a new technology that allows the rapid development of H3N2 vaccines. They created a new cell-line that allowed for the faster growth of H3N2 to be used in vaccines. These research findings will be useful in the introduction of new products to this market.

Regional Insights

North America was the most represented country with 43.1% of the total in 2019. Due to an increase in funding initiatives by government agencies, the region will continue to hold its lead position over the next years. This has accelerated the production of stem cells as well as the development of regenerative medicine products and cellular therapy products. This drives demand for cell expansion platforms within the region.

In October 2019, for example, the FDA and MTEC provided funding totaling USD 5.3 millions to the Southwest Research Institute (SwRI). These funds were used by the SwRI to grow cells for personalized regenerative medicine. These investments increase the region's revenue generation.

Asia Pacific is expected see the most rapid growth over the forecast period, due to the increasing efforts of several local biotechnology and pharmaceutical companies to commercialize and develop cellular therapies. An Indian company, Stempeutics Research Pvt. Ltd. signed an alliance in July 2019 with Kemwell Biopharma for the commercialization its stem-cell-based product, Stempeucel. These agreements can boost product sales for small and medium-sized companies.

Market Share Insights & Key Companies

To expand their market presence, key market players are pursuing several initiatives. They are also involved in product development, collaborations, agreements, and business expansion strategies for untapped areas.

Demcon, for example, purchased a stake in Scinus Cell Expansion B.V. in June 2019. This Dutch manufacturer of stem-cell-based therapy equipment. Scinus was able to grow its stem cell therapy business through this acquisition. These growth initiatives will increase the utilization rate for bioreactors that are used to cultivate stem cells and thereby lead to market growth. The cell expansion market is dominated by the following players:

• Thermo Fisher Scientific, Inc.

• GE Healthcare

• Corning, Inc.

• STEMCELL Technologies, Inc.

• Merck KGaA

• Miltenyi Biotec

• Becton, Dickinson and Company

• Terumo Bct, Inc.

• Sartorius AG

• Takara Bio, Inc.

• Trinova Biochem GmbH

• upcyte technology GmbH

Up Market Research published a new report titled “Cell Expansion Market research report which is segmented by Product (Consumables, Instruments), by Cell Type (Animal, Mammalian), By Players/Companies Thermo Fisher Scientific Inc, Miltenyi Biotec, Sartorius AG, Becton Dickinson and Company, Corning Inc, Terumo Bct Inc, Takara Bio Inc, Trinova Biochem GmbH, upcyte technologies GmbH, GE Healthcare, Merck KGaA, STEMCELL Technologies Inc”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.

Report Scope

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.

Global Cell Expansion Market Report Segments:

The market is segmented by Product (Consumables, Instruments), by Cell Type (Animal, Mammalian).

Cell Expansion Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.

Key Benefits for Industry Participants & Stakeholders:

• Industry drivers, restraints, and opportunities covered in the study
• Neutral perspective on the market performance
• Recent industry trends and developments
• Competitive landscape & strategies of key players
• Potential & niche segments and regions exhibiting promising growth covered
• Historical, current, and projected market size, in terms of value
• In-depth analysis of the Cell Expansion Market

Overview of the regional outlook of the Cell Expansion Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.

Highlights of The Cell Expansion Market Report:

1. The market structure and projections for the coming years.
2. Drivers, restraints, opportunities, and current trends of Cell Expansion Market.
3. Historical data and forecast.
4. Estimations for the forecast period 2028.
5. Developments and trends in the market.

                1. Consumables

                2. Instruments

                1. Animal

                2. Mammalian

8. Market scenario by region, sub-region, and country.
9. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
10. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
11. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the Cell Expansion Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.

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Reasons to Purchase the Cell Expansion Market Report:

• The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
• Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
• Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
• The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
• Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.