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Global Anti-Vascular Endothelial Growth Factor Therapeutics Market by Disease (AMD, Diabetic Retinopathy), by Product (Beovu, Eylea) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

  • Report ID: PH-69792
  • Author: Up Market Research
  • Rating: 5.0
  • Total Reviews: 60
  • No. Of Pages: 215
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  • Pub. Date: 2021-10-14
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Summary of the Report

Global anti-vascular growth factor therapeutics market was valued at USD 11.67 Billion in 2020. It is expected to increase at a compound annual rate (CAGR of 0.5%) between 2021 and 2028. Market growth in anti-Vascular Endothelial Growth Factor therapeutics can be attributed to an increased prevalence of ophthalmic conditions such as macular edema and diabetic retinopathy, retinal occlusion, Age-related Macular Degeneration, and retinal vein occlusion. There is also an increase in the number of geriatrics who are at risk for developing this condition. The WHO estimates that AMD affects around 196 million people worldwide, with more than 10.4 million suffering from severe to moderate vision impairment. The market is also growing due to product launches and technological advancements.

AMD is the most common cause of vision loss in Canada. It affected approximately 1.4 million people in 2018. According to the European Union, around 34 million people suffered from AMD in 2017. A major market driver is also the alarmingly rising prevalence of diabetes worldwide. According to the Lancet journal, the annual incidence of diabetic retinalopathy is between 12.7% and 2.2% in 2018.

In addition, due to the increasing geriatric population, eye diseases are expected to rise in the future. WHO estimates that the population of older people has grown to 60 million, compared with 5 million children under 5. The geriatric population will reach around 2 billion by 2050 from 900 million in 2015. Globally, there are 125 million people aged 80 and over.

Market players are shifting their focus to longer-acting, VEGF-based products and treatments for these conditions. Novartis' 2019 launch of brolucizumab has increased the competition between the drugs on the market. The longer-acting VEGF medication Beovu (brolucizumab), was introduced in 2019. It has a 3 month loading dose and is then administered every 8 to 12 week.

The companies are also developing new formulations and delivery systems to increase the use of these therapies. F. Hoffmann La Roche Ltd., for instance, is currently undergoing a clinical trial in phase III. This eye implant is refillable and delivers ranibizumab continuously over a number of months.

Market growth is negatively affected by low rates of screening and diagnosis in developing countries for diabetic retinopathy. Market growth is also impeded by the high risk of intraocular injury in anti-VEGF therapy. Patent cliff is another major issue in the pharmaceutical industry. Major blockbuster drugs account for a large portion of turnovers.

Due to the expiry of the patent for Lucentis in the U.S. and Europe in June 2020, key players are involved in developing biosimilars. CoherusBioSciences, Inc. signed a license-and-development agreement with BioeqIP AG in November 2019 for commercialization of Lucentis biosimilars in the U.S. The company plans to bring the product to the market by 2021. This will increase the cost-effectiveness and make it more accessible to a wider range of patients.

Product Insights

With a revenue share exceeding 67%, the Eylea product category dominated the global market for 2020. It is expected to continue its dominance during the forecast period. Due to the advancements in formulations, and the development advanced drug delivery systems, this product will see significant demand. Bayer AG announced in April 2020 that Eylea injection-prefilled syringes will be available in the EU market. This product is currently valid in all 27 EU member countries.

Because it is easy to administer, this new formulation could increase product adoption among ophthalmologists. Beovuis is expected to experience the fastest CAGR during the forecast period due to its patent exclusivity and geographic expansion. Novartis AG announced in February 2020 that the EC approved Beovu (brolucizumab), an injection to treat WAMD. All 27 EU member countries are eligible for the EC approval. Approval of the product in a new geographical area may increase sales and expand customer base.

Disease Insights

Age-related Macular Degeneration (AMD), which accounted for more than 86% of the total market, was the largest segment. This is due to an increasing disease burden, growing elderly population, and the presence of late-stage product candidate candidates that will be entering the market over the next few years. REGENXBIO Inc. is currently conducting a phase II clinical study on its pipeline candidate, RGX-314. It should be ready for commercialization by the end 2023.

Due to the unmet medical need and increasing numbers of diabetic retinopathy treatment approvals, the segment of diabetic-retinopathy is expected to grow at a fastest CAGR over the next few years. Globally, 56% of cases of visual impairment are caused by retinopathy. One-fifth the population of diabetics is affected. Regeneron Pharmaceuticals was approved by the FDA in May 2019 to treat all stages of diabetic retinalopathy. This approval could help fuel growth.

Regional Insights

The North America region had the largest revenue share, more than 64%, in the global market for 2020. Over the forecast period, the regional market will experience a significant increase in sales. The regional market is expected to grow due to factors such as rising disease prevalence, consumer awareness, proactive government actions, technological advances, and improvements in healthcare infrastructure. Market growth will be supported by the presence of major players in North America. F. Hoffmann-La Roche Ltd. has announced the top line clinical trials results of formulation advancement for ranibizumab using Port Delivery System.

These delivery systems, which include technological advances and product launches, are expected to have a positive impact on the market growth. Asia Pacific will grow at a 2.4% CAGR between 2021 and 2028. The key factors driving regional market growth are rising disposable income, increased anti-VEGF product penetration, and increasing consumer awareness. The government may also be taking more initiatives to increase product adoption.

Market Share Insights & Key Companies

Companies are creating strategies that enable them to make use of their resources to help develop new products. F. Hoffmann-La Roche Ltd., for instance, announced positive top-line results from the global phase III study evaluating faricimab among people with DME in December 2020. Faricimab was tolerated well with no safety warnings. The following are some of the major players in the global anti VEGF therapeutics market:

  • F. Hoffmann-La Roche Ltd.

  • Biogen

  • Pfizer, Inc.

  • CoherusBioSciences

  • Amgen, Inc.

  • Bausch Health Companies, Inc.

  • Viatris, Inc.

Up Market Research published a new report titled “Anti-Vascular Endothelial Growth Factor Therapeutics Market research report which is segmented by Disease (AMD, Diabetic Retinopathy), by Product (Beovu, Eylea), By Players/Companies CoherusBioSciences, Viatris Inc, Pfizer Inc, Biogen, Bausch Health Companies Inc, F Hoffmann-La Roche Ltd, Amgen Inc”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.


Report Scope

Report AttributesReport Details
Report TitleAnti-Vascular Endothelial Growth Factor Therapeutics Market Research Report
By DiseaseAMD, Diabetic Retinopathy
By ProductBeovu, Eylea
By CompaniesCoherusBioSciences, Viatris Inc, Pfizer Inc, Biogen, Bausch Health Companies Inc, F Hoffmann-La Roche Ltd, Amgen Inc
Regions CoveredNorth America, Europe, APAC, Latin America, MEA
Base Year2020
Historical Year2018 to 2019 (Data from 2010 can be provided as per availability)
Forecast Year2028
Number of Pages215
Number of Tables & Figures151
Customization AvailableYes, the report can be customized as per your need.

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.


Global Anti-Vascular Endothelial Growth Factor Therapeutics Industry Outlook

Global Anti-Vascular Endothelial Growth Factor Therapeutics Market Report Segments:

The market is segmented by Disease (AMD, Diabetic Retinopathy), by Product (Beovu, Eylea).

Anti-Vascular Endothelial Growth Factor Therapeutics Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.


Key Benefits for Industry Participants & Stakeholders:

  • Industry drivers, restraints, and opportunities covered in the study
  • Neutral perspective on the market performance
  • Recent industry trends and developments
  • Competitive landscape & strategies of key players
  • Potential & niche segments and regions exhibiting promising growth covered
  • Historical, current, and projected market size, in terms of value
  • In-depth analysis of the Anti-Vascular Endothelial Growth Factor Therapeutics Market

Overview of the regional outlook of the Anti-Vascular Endothelial Growth Factor Therapeutics Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.


Anti-Vascular Endothelial Growth Factor Therapeutics Market Overview

Highlights of The Anti-Vascular Endothelial Growth Factor Therapeutics Market Report:

  1. The market structure and projections for the coming years.
  2. Drivers, restraints, opportunities, and current trends of Anti-Vascular Endothelial Growth Factor Therapeutics Market.
  3. Historical data and forecast.
  4. Estimations for the forecast period 2028.
  5. Developments and trends in the market.
        6. By Disease:

                1. AMD

                2. Diabetic Retinopathy

        7. By Product:

                1. Beovu

                2. Eylea

  1. Market scenario by region, sub-region, and country.
  2. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
  3. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
  4. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the Anti-Vascular Endothelial Growth Factor Therapeutics Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.


How you may use our products:

  • Correctly Positioning New Products
  • Market Entry Strategies
  • Business Expansion Strategies
  • Consumer Insights
  • Understanding Competition Scenario
  • Product & Brand Management
  • Channel & Customer Management
  • Identifying Appropriate Advertising Appeals

Anti-Vascular Endothelial Growth Factor Therapeutics Market Trends

Reasons to Purchase the Anti-Vascular Endothelial Growth Factor Therapeutics Market Report:

  • The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
  • Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
  • Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
  • The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
  • Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.
Chapter 1 Executive Summary
Chapter 2 Assumptions and Acronyms Used
Chapter 3 Research Methodology
Chapter 4 Anti-Vascular Endothelial Growth Factor Therapeutics Market Overview
   4.1 Introduction 
      4.1.1 Market Taxonomy 
      4.1.2 Market Definition 
      4.1.3 Macro-Economic Factors Impacting the Market Growth 
   4.2 Anti-Vascular Endothelial Growth Factor Therapeutics Market Dynamics 
      4.2.1 Market Drivers 
      4.2.2 Market Restraints 
      4.2.3 Market Opportunity 
   4.3 Anti-Vascular Endothelial Growth Factor Therapeutics Market - Supply Chain Analysis 
      4.3.1 List of Key Suppliers 
      4.3.2 List of Key Distributors 
      4.3.3 List of Key Consumers 
   4.4 Key Forces Shaping the Anti-Vascular Endothelial Growth Factor Therapeutics Market 
      4.4.1 Bargaining Power of Suppliers 
      4.4.2 Bargaining Power of Buyers 
      4.4.3 Threat of Substitution 
      4.4.4 Threat of New Entrants 
      4.4.5 Competitive Rivalry 
   4.5 Global Anti-Vascular Endothelial Growth Factor Therapeutics Market Size & Forecast, 2018-2028 
      4.5.1 Anti-Vascular Endothelial Growth Factor Therapeutics Market Size and Y-o-Y Growth 
      4.5.2 Anti-Vascular Endothelial Growth Factor Therapeutics Market Absolute $ Opportunity 


Chapter 5 Global Anti-Vascular Endothelial Growth Factor Therapeutics Market Analysis and Forecast by Disease
   5.1 Introduction
      5.1.1 Key Market Trends & Growth Opportunities by Disease
      5.1.2 Basis Point Share (BPS) Analysis by Disease
      5.1.3 Absolute $ Opportunity Assessment by Disease
   5.2 Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Disease
      5.2.1 AMD
      5.2.2 Diabetic Retinopathy
   5.3 Market Attractiveness Analysis by Disease

Chapter 6 Global Anti-Vascular Endothelial Growth Factor Therapeutics Market Analysis and Forecast by Product
   6.1 Introduction
      6.1.1 Key Market Trends & Growth Opportunities by Product
      6.1.2 Basis Point Share (BPS) Analysis by Product
      6.1.3 Absolute $ Opportunity Assessment by Product
   6.2 Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Product
      6.2.1 Beovu
      6.2.2 Eylea
   6.3 Market Attractiveness Analysis by Product

Chapter 7 Global Anti-Vascular Endothelial Growth Factor Therapeutics Market Analysis and Forecast by Region
   7.1 Introduction
      7.1.1 Key Market Trends & Growth Opportunities by Region
      7.1.2 Basis Point Share (BPS) Analysis by Region
      7.1.3 Absolute $ Opportunity Assessment by Region
   7.2 Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Region
      7.2.1 North America
      7.2.2 Europe
      7.2.3 Asia Pacific
      7.2.4 Latin America
      7.2.5 Middle East & Africa (MEA)
   7.3 Market Attractiveness Analysis by Region

Chapter 8 Coronavirus Disease (COVID-19) Impact 
   8.1 Introduction 
   8.2 Current & Future Impact Analysis 
   8.3 Economic Impact Analysis 
   8.4 Government Policies 
   8.5 Investment Scenario

Chapter 9 North America Anti-Vascular Endothelial Growth Factor Therapeutics Analysis and Forecast
   9.1 Introduction
   9.2 North America Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Country
      9.2.1 U.S.
      9.2.2 Canada
   9.3 Basis Point Share (BPS) Analysis by Country
   9.4 Absolute $ Opportunity Assessment by Country
   9.5 Market Attractiveness Analysis by Country
   9.6 North America Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Disease
      9.6.1 AMD
      9.6.2 Diabetic Retinopathy
   9.7 Basis Point Share (BPS) Analysis by Disease 
   9.8 Absolute $ Opportunity Assessment by Disease 
   9.9 Market Attractiveness Analysis by Disease
   9.10 North America Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Product
      9.10.1 Beovu
      9.10.2 Eylea
   9.11 Basis Point Share (BPS) Analysis by Product 
   9.12 Absolute $ Opportunity Assessment by Product 
   9.13 Market Attractiveness Analysis by Product

Chapter 10 Europe Anti-Vascular Endothelial Growth Factor Therapeutics Analysis and Forecast
   10.1 Introduction
   10.2 Europe Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Country
      10.2.1 Germany
      10.2.2 France
      10.2.3 Italy
      10.2.4 U.K.
      10.2.5 Spain
      10.2.6 Russia
      10.2.7 Rest of Europe
   10.3 Basis Point Share (BPS) Analysis by Country
   10.4 Absolute $ Opportunity Assessment by Country
   10.5 Market Attractiveness Analysis by Country
   10.6 Europe Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Disease
      10.6.1 AMD
      10.6.2 Diabetic Retinopathy
   10.7 Basis Point Share (BPS) Analysis by Disease 
   10.8 Absolute $ Opportunity Assessment by Disease 
   10.9 Market Attractiveness Analysis by Disease
   10.10 Europe Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Product
      10.10.1 Beovu
      10.10.2 Eylea
   10.11 Basis Point Share (BPS) Analysis by Product 
   10.12 Absolute $ Opportunity Assessment by Product 
   10.13 Market Attractiveness Analysis by Product

Chapter 11 Asia Pacific Anti-Vascular Endothelial Growth Factor Therapeutics Analysis and Forecast
   11.1 Introduction
   11.2 Asia Pacific Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Country
      11.2.1 China
      11.2.2 Japan
      11.2.3 South Korea
      11.2.4 India
      11.2.5 Australia
      11.2.6 South East Asia (SEA)
      11.2.7 Rest of Asia Pacific (APAC)
   11.3 Basis Point Share (BPS) Analysis by Country
   11.4 Absolute $ Opportunity Assessment by Country
   11.5 Market Attractiveness Analysis by Country
   11.6 Asia Pacific Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Disease
      11.6.1 AMD
      11.6.2 Diabetic Retinopathy
   11.7 Basis Point Share (BPS) Analysis by Disease 
   11.8 Absolute $ Opportunity Assessment by Disease 
   11.9 Market Attractiveness Analysis by Disease
   11.10 Asia Pacific Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Product
      11.10.1 Beovu
      11.10.2 Eylea
   11.11 Basis Point Share (BPS) Analysis by Product 
   11.12 Absolute $ Opportunity Assessment by Product 
   11.13 Market Attractiveness Analysis by Product

Chapter 12 Latin America Anti-Vascular Endothelial Growth Factor Therapeutics Analysis and Forecast
   12.1 Introduction
   12.2 Latin America Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Country
      12.2.1 Brazil
      12.2.2 Mexico
      12.2.3 Rest of Latin America (LATAM)
   12.3 Basis Point Share (BPS) Analysis by Country
   12.4 Absolute $ Opportunity Assessment by Country
   12.5 Market Attractiveness Analysis by Country
   12.6 Latin America Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Disease
      12.6.1 AMD
      12.6.2 Diabetic Retinopathy
   12.7 Basis Point Share (BPS) Analysis by Disease 
   12.8 Absolute $ Opportunity Assessment by Disease 
   12.9 Market Attractiveness Analysis by Disease
   12.10 Latin America Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Product
      12.10.1 Beovu
      12.10.2 Eylea
   12.11 Basis Point Share (BPS) Analysis by Product 
   12.12 Absolute $ Opportunity Assessment by Product 
   12.13 Market Attractiveness Analysis by Product

Chapter 13 Middle East & Africa (MEA) Anti-Vascular Endothelial Growth Factor Therapeutics Analysis and Forecast
   13.1 Introduction
   13.2 Middle East & Africa (MEA) Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Country
      13.2.1 Saudi Arabia
      13.2.2 South Africa
      13.2.3 UAE
      13.2.4 Rest of Middle East & Africa (MEA)
   13.3 Basis Point Share (BPS) Analysis by Country
   13.4 Absolute $ Opportunity Assessment by Country
   13.5 Market Attractiveness Analysis by Country
   13.6 Middle East & Africa (MEA) Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Disease
      13.6.1 AMD
      13.6.2 Diabetic Retinopathy
   13.7 Basis Point Share (BPS) Analysis by Disease 
   13.8 Absolute $ Opportunity Assessment by Disease 
   13.9 Market Attractiveness Analysis by Disease
   13.10 Middle East & Africa (MEA) Anti-Vascular Endothelial Growth Factor Therapeutics Market Size Forecast by Product
      13.10.1 Beovu
      13.10.2 Eylea
   13.11 Basis Point Share (BPS) Analysis by Product 
   13.12 Absolute $ Opportunity Assessment by Product 
   13.13 Market Attractiveness Analysis by Product

Chapter 14 Competition Landscape 
   14.1 Anti-Vascular Endothelial Growth Factor Therapeutics Market: Competitive Dashboard
   14.2 Global Anti-Vascular Endothelial Growth Factor Therapeutics Market: Market Share Analysis, 2019
   14.3 Company Profiles (Details – Overview, Financials, Developments, Strategy) 
      14.3.1 CoherusBioSciences
      14.3.2 Viatris Inc
      14.3.3 Pfizer Inc
      14.3.4 Biogen
      14.3.5 Bausch Health Companies Inc
      14.3.6 F Hoffmann-La Roche Ltd
      14.3.7 Amgen Inc
Segments Covered in the Report
The global Anti-Vascular Endothelial Growth Factor Therapeutics market has been segmented based on

By Disease
  • AMD
  • Diabetic Retinopathy
By Product
  • Beovu
  • Eylea
Regions
  • Asia Pacific
  • North America
  • Latin America
  • Europe
  • Middle East & Africa
Key Players
  • CoherusBioSciences
  • Viatris Inc
  • Pfizer Inc
  • Biogen
  • Bausch Health Companies Inc
  • F Hoffmann-La Roche Ltd
  • Amgen Inc

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