Global anti-vascular growth factor therapeutics market was valued at USD 11.67 Billion in 2020. It is expected to increase at a compound annual rate (CAGR of 0.5%) between 2021 and 2028. Market growth in anti-Vascular Endothelial Growth Factor therapeutics can be attributed to an increased prevalence of ophthalmic conditions such as macular edema and diabetic retinopathy, retinal occlusion, Age-related Macular Degeneration, and retinal vein occlusion. There is also an increase in the number of geriatrics who are at risk for developing this condition. The WHO estimates that AMD affects around 196 million people worldwide, with more than 10.4 million suffering from severe to moderate vision impairment. The market is also growing due to product launches and technological advancements.
AMD is the most common cause of vision loss in Canada. It affected approximately 1.4 million people in 2018. According to the European Union, around 34 million people suffered from AMD in 2017. A major market driver is also the alarmingly rising prevalence of diabetes worldwide. According to the Lancet journal, the annual incidence of diabetic retinalopathy is between 12.7% and 2.2% in 2018.
In addition, due to the increasing geriatric population, eye diseases are expected to rise in the future. WHO estimates that the population of older people has grown to 60 million, compared with 5 million children under 5. The geriatric population will reach around 2 billion by 2050 from 900 million in 2015. Globally, there are 125 million people aged 80 and over.
Market players are shifting their focus to longer-acting, VEGF-based products and treatments for these conditions. Novartis' 2019 launch of brolucizumab has increased the competition between the drugs on the market. The longer-acting VEGF medication Beovu (brolucizumab), was introduced in 2019. It has a 3 month loading dose and is then administered every 8 to 12 week.
The companies are also developing new formulations and delivery systems to increase the use of these therapies. F. Hoffmann La Roche Ltd., for instance, is currently undergoing a clinical trial in phase III. This eye implant is refillable and delivers ranibizumab continuously over a number of months.
Market growth is negatively affected by low rates of screening and diagnosis in developing countries for diabetic retinopathy. Market growth is also impeded by the high risk of intraocular injury in anti-VEGF therapy. Patent cliff is another major issue in the pharmaceutical industry. Major blockbuster drugs account for a large portion of turnovers.
Due to the expiry of the patent for Lucentis in the U.S. and Europe in June 2020, key players are involved in developing biosimilars. CoherusBioSciences, Inc. signed a license-and-development agreement with BioeqIP AG in November 2019 for commercialization of Lucentis biosimilars in the U.S. The company plans to bring the product to the market by 2021. This will increase the cost-effectiveness and make it more accessible to a wider range of patients.
With a revenue share exceeding 67%, the Eylea product category dominated the global market for 2020. It is expected to continue its dominance during the forecast period. Due to the advancements in formulations, and the development advanced drug delivery systems, this product will see significant demand. Bayer AG announced in April 2020 that Eylea injection-prefilled syringes will be available in the EU market. This product is currently valid in all 27 EU member countries.
Because it is easy to administer, this new formulation could increase product adoption among ophthalmologists. Beovuis is expected to experience the fastest CAGR during the forecast period due to its patent exclusivity and geographic expansion. Novartis AG announced in February 2020 that the EC approved Beovu (brolucizumab), an injection to treat WAMD. All 27 EU member countries are eligible for the EC approval. Approval of the product in a new geographical area may increase sales and expand customer base.
Age-related Macular Degeneration (AMD), which accounted for more than 86% of the total market, was the largest segment. This is due to an increasing disease burden, growing elderly population, and the presence of late-stage product candidate candidates that will be entering the market over the next few years. REGENXBIO Inc. is currently conducting a phase II clinical study on its pipeline candidate, RGX-314. It should be ready for commercialization by the end 2023.
Due to the unmet medical need and increasing numbers of diabetic retinopathy treatment approvals, the segment of diabetic-retinopathy is expected to grow at a fastest CAGR over the next few years. Globally, 56% of cases of visual impairment are caused by retinopathy. One-fifth the population of diabetics is affected. Regeneron Pharmaceuticals was approved by the FDA in May 2019 to treat all stages of diabetic retinalopathy. This approval could help fuel growth.
The North America region had the largest revenue share, more than 64%, in the global market for 2020. Over the forecast period, the regional market will experience a significant increase in sales. The regional market is expected to grow due to factors such as rising disease prevalence, consumer awareness, proactive government actions, technological advances, and improvements in healthcare infrastructure. Market growth will be supported by the presence of major players in North America. F. Hoffmann-La Roche Ltd. has announced the top line clinical trials results of formulation advancement for ranibizumab using Port Delivery System.
These delivery systems, which include technological advances and product launches, are expected to have a positive impact on the market growth. Asia Pacific will grow at a 2.4% CAGR between 2021 and 2028. The key factors driving regional market growth are rising disposable income, increased anti-VEGF product penetration, and increasing consumer awareness. The government may also be taking more initiatives to increase product adoption.
Companies are creating strategies that enable them to make use of their resources to help develop new products. F. Hoffmann-La Roche Ltd., for instance, announced positive top-line results from the global phase III study evaluating faricimab among people with DME in December 2020. Faricimab was tolerated well with no safety warnings. The following are some of the major players in the global anti VEGF therapeutics market:
F. Hoffmann-La Roche Ltd.
Biogen
Pfizer, Inc.
CoherusBioSciences
Amgen, Inc.
Bausch Health Companies, Inc.
Viatris, Inc.
Up Market Research published a new report titled “Anti-Vascular Endothelial Growth Factor Therapeutics Market research report which is segmented by Disease (AMD, Diabetic Retinopathy), by Product (Beovu, Eylea), By Players/Companies CoherusBioSciences, Viatris Inc, Pfizer Inc, Biogen, Bausch Health Companies Inc, F Hoffmann-La Roche Ltd, Amgen Inc”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.
Report Attributes | Report Details |
Report Title | Anti-Vascular Endothelial Growth Factor Therapeutics Market Research Report |
By Disease | AMD, Diabetic Retinopathy |
By Product | Beovu, Eylea |
By Companies | CoherusBioSciences, Viatris Inc, Pfizer Inc, Biogen, Bausch Health Companies Inc, F Hoffmann-La Roche Ltd, Amgen Inc |
Regions Covered | North America, Europe, APAC, Latin America, MEA |
Base Year | 2020 |
Historical Year | 2018 to 2019 (Data from 2010 can be provided as per availability) |
Forecast Year | 2028 |
Number of Pages | 215 |
Number of Tables & Figures | 151 |
Customization Available | Yes, the report can be customized as per your need. |
The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.
The market is segmented by Disease (AMD, Diabetic Retinopathy), by Product (Beovu, Eylea).
Anti-Vascular Endothelial Growth Factor Therapeutics Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.
Key Benefits for Industry Participants & Stakeholders:
Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.
We have studied the Anti-Vascular Endothelial Growth Factor Therapeutics Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.
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