Global 3D Cell Culture Market by Application (Stem Cell Research, Cancer), by Technology (Scaffold-free, Scaffold-based) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

Summary of the Report

Global 3D cell culture market was valued at USD 1.5 Billion in 2020. It is forecast to grow at a compound annual rate (CAGR), of 10.7% over the forecast period. Because 3D cultures are able to closely replicate the morphology and microarchitectures of organs, they are often used in studies that need in-vivo models systems to study the effects of foreign drugs on body tissues and organs. Biomimetic tissue constructs that can generate 3D organotypic shapes drove many research organizations to adopt 3-dimensional cell cultivation techniques. As an alternative to traditional methods, 3D tissue-engineered models have been developed for Covid-19, cancer and other clinical disorders. This is a great alternative to traditional 2D techniques because it provides a simple, inexpensive, and easy-to-use in vitro environment for tumor-hosts.

Market growth is expected to be significant due to the high utility of 3-dimensional models in research on Covid-19 and other respiratory diseases. As tools to develop and discover antiviral drugs and experimental virology platforms for studying the immune responses and infectivity, airway and liquid interface organoids were used. Bio-fabrication of realistic models can be done using scaffold-based or scaffold-free methods. These models can then be used to develop new therapeutics and vaccines for Covid-19.

Other factors that drive market growth include new products being launched and wider applications of 3D protocols in biology research. eNUVIO Inc., a Canadian biotechnology company, introduced EB-Plate in December 2020. This is a completely reusable microplate that can be used for 3D cell cultivation. This will reduce single-use plastic waste, increase the utility and promote zero-waste in laboratories.

Similar to the 2D analysis method, you can also apply it to RAFT 3D culture manufactured by Lonza. These new technologies are widely adopted by laboratories around the world because they don't require any changes to existing 2D culture methods. Lonza also created 3D cell culture models for research in the areas of drug-induced liver injury and hepatic signaling pathways to aid in in vitro hepatotoxicity testing.

Technology Insights

In 2020, scaffold-based technology was responsible for the highest revenue share at over 68.96%. Hydrogels are used as scaffolds in 3-dimensional cell-culture-based research. This allows for sophisticated biochemical and mechanical signals to be incorporated as a mirror of native extracellular matrix. Market growth is expected to be boosted by the introduction of new products and the need for better hydrogels that provide robust platforms for studying human and cell physiology.

Researchers from China's Southern University of Science and Technology developed a 3D printing method to create highly stretchable hydrogels in January 2021. This helps overcome the limitations associated with the performance and functionality of hydrogel-polymer-based scaffolds. Adocia, a biopharmaceutical company based in Paris, created a hydrogel scaffold for Type 1 diabetes cell therapy.

There are potential growth opportunities for scaffold-based nanofiber technology due to the increasing popularity and awareness of nanotechnology in biomedical research. Magnetic levitational assembly 3D tissue constructs using magnetic levitational assembly is a fast-growing and scaffold-free method for tissue engineering. This segment is expected to have the fastest predicted CAGR.

Application Insights

With a 24.56% revenue share in 2020, the cancer segment was the dominant market. This segment is driven by R&D because of the use of spheroids in anticancer therapy development. This segment is also expected to see an increase in revenue from the use of 3-dimensional cell models for studying cancer biology in preclinical screening and testing.

In a January 2021 research paper, the researchers reported on the creation of 3D printed polysaccharide tumor models. These can be used to screen high-throughput anti-cancer drugs. The researchers sought to develop hydrogel that mimics the tumor microenvironment and has appropriate biocompatibility, characteristics, and printability. These developments have led to an increase in the use of scaffold-based cancer treatments.

From 2021 to 2028, the segment of stem cell research is expected to experience the highest CAGR. The segment is expected to grow due to increased use of 3D cell culture platforms for regenerative medicine. Histogen, Inc., a company that develops regenerative medicine, merged with Conatus Pharmaceuticals, Inc. in January 2020. This company has a strong pipeline of clinical candidates that includes an extracellular matrix scaffold for the treatment of conditions related to articular cartilage.

End-use Insights

In 2020, the biotechnology and pharmaceutical industry segment accounted for 46% of total revenue. 3D cell culture has advantages over 2D cell culture for studying drug candidates. They can provide optimal oxygen and nutrients gradients, as well as non-uniform drug exposure. These factors make 3D cells more suitable for drug discovery and development. This drives the market.

Hospitals and diagnostic centers are seeing a rise in their segment due to factors such as the need for faster and more accurate diagnostic services, and the benefits of 3D models over 2D models when providing detailed physiological information. The segment will continue to grow due to the active involvement of diagnostic centers like Kiyatec in providing 3D models for advanced studies.

This market will grow in importance due to increased participation from academic institutes and industrial labs. The demand for 3D cells culture products and systems is expected to rise over the forecast period due to workshops and training programs offered by institutes.

Regional Insights

North America dominated the global market in 2020, accounting for over 43% of the total revenue. Because of the availability and high level of healthcare spending and the availability of funding from the private and public sectors for advanced 3D cell culture models and other stem-cell-based research, the region will continue to be the market leader throughout the forecast period. Researchers from the Terasaki Institute and Mayo Clinic, U.S. developed visible hydrogels for monitoring and controlling hemorhage.

Regenerative medicine is recognized as a leading area of healthcare in the U.S. Department of Health and Human Services' "2020: A New Vision" initiative. Regenerative medicine's transformative effects at the clinical stage is crucial for technological innovation and translational progress. Due to increased investments by international companies in emerging economies, Asia Pacific will be the fastest-growing region market between 2021 and 2028.

Market Share Insights & Key Companies

To increase market presence, major market players are focusing their efforts on new product launches and partnerships with other players. Corning, Inc., for gene and cell therapy applications, introduced the Corning XSERIES cell processing platform in June 2020. This platform allows for sterile, efficient, automated, and fast processing. ThermoGenesis Holdings, Inc. manufactured this product. Corning Matrigel matrix-3D plates were also introduced by the company in the same month. These plates are a convenient, consistent and ready-to-use option for cell culture to support organoid or spheroid models. The following are some of the major players in the global 3D cell-culture market:

• Merck KGaA

• Thermo Fisher Scientific, Inc.

• PromoCell GmbH

• Greiner Bio One International GmbH

• Corning, Inc.

• 3D Biomatrix

• Lonza

• Avantor Performance Materials, LLC

• Tecan Trading AG

• 3D Biotek LLC

• Global Cell Solutions, Inc.

• InSphero

Up Market Research published a new report titled “3D Cell Culture Market research report which is segmented by Application (Stem Cell Research, Cancer), by Technology (Scaffold-free, Scaffold-based), By Players/Companies InSphero, 3D Biotek LLC, PromoCell GmbH, Tecan Trading AG, Thermo Fisher Scientific Inc, Lonza, Avantor Performance Materials LLC, Corning Inc, Merck KGaA, Global Cell Solutions Inc, Greiner Bio One International GmbH, 3D Biomatrix”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.

Report Scope

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.

Global 3D Cell Culture Market Report Segments:

The market is segmented by Application (Stem Cell Research, Cancer), by Technology (Scaffold-free, Scaffold-based).

3D Cell Culture Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.

Key Benefits for Industry Participants & Stakeholders:

• Industry drivers, restraints, and opportunities covered in the study
• Neutral perspective on the market performance
• Recent industry trends and developments
• Competitive landscape & strategies of key players
• Potential & niche segments and regions exhibiting promising growth covered
• Historical, current, and projected market size, in terms of value
• In-depth analysis of the 3D Cell Culture Market

Overview of the regional outlook of the 3D Cell Culture Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.

Highlights of The 3D Cell Culture Market Report:

1. The market structure and projections for the coming years.
2. Drivers, restraints, opportunities, and current trends of 3D Cell Culture Market.
3. Historical data and forecast.
4. Estimations for the forecast period 2028.
5. Developments and trends in the market.

                1. Stem Cell Research

                2. Cancer

                1. Scaffold-free

                2. Scaffold-based

8. Market scenario by region, sub-region, and country.
9. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
10. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
11. Government Policies, Macro & Micro economic factors are also included in the report.

We have studied the 3D Cell Culture Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.

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Reasons to Purchase the 3D Cell Culture Market Report:

• The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
• Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
• Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
• The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
• Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.