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Global Immune Checkpoint Inhibitors Market by Type (PD-1/PD-L1, CTLA-4), By Application (Lung Cancer, Colorectal Cancer, Breast Cancer, Prostate Cancer, Melanoma, Blood Cancer, Other) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028

  • Report ID: PH-706
  • Author: Up Market Research
  • Rating: 5.0
  • Total Reviews: 77
  • No. Of Pages: 240
  • Format:
  • Pub. Date: 2021-03-01
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The Global Immune Checkpoint Inhibitors Market size is projected to grow from $14 billion in 2021 with a CAGR of 19% during the forecast period from 2021-2028. The major factors driving growth in this market are the increasing prevalence of cancer and rising incidence rates for various types of cancer globally, coupled with the high efficacy and safety profile of these drugs thus giving rise to an urgent need to develop new treatments for cancer that can improve quality of life as well as patient survival rate.

 

Immune Checkpoint Inhibitors are drugs that block one of the brakes on our immune system. Immune checkpoints are special proteins located on a cell surface that can tell other cells whether to attack it or not. When these signals aren’t functioning correctly, cancer cells may escape the body's natural defenses and start growing out of control (progression). The drugs called "immune checkpoint inhibitors" target those checkpoints in order to help with this problem - they either stop them from being active at all or increase their activity so there is more opportunity for an attacking T-cell to bind onto them before anything else happens.

 

On the basis of Types, the market is segmented into PD-I/PD-Ll (Nivolumab, Opdivo), CTLA-IV (ipilimumab), and Others.

 

PD-I/PD-Ll (Nivolumab, Opdivo):

Nivolumab is a type of immune checkpoint inhibitor drug that blocks PD-Ll, which suppresses the activity of CD28 and CTLA-I. Opdivo also comes from this class of drugs and it targets both PD-Ll and PD-LI. It can be used to treat cancer by blocking these receptors on T cells so they are able to attack cancerous cells in the body more effectively. Nivolumab and Opdivo are used to treat cancer. They both interfere with T-cells, which can typically fight against the growth of cancerous cells in the body.

 

CTLA-IV (Ipilimumab):

CTLA-IV (ipilimumab) can be defined as an immune checkpoint inhibitor. CTLA-IV (ipilimumab) is used to treat cancer and it can block the body's tumor defense system from working normally. It belongs to a group of medications called monoclonal antibodies, which are proteins that fight off diseases or viruses by sticking themselves onto them so they cannot work properly. The effects of this medication last for about two years on average but some people have had it as long as five years before their tumors came back more aggressively than before.

 

On the basis of Application, the market is segmented into Lung Cancer, Colorectal Cancer, Breast Cancer, Prostate Cancer, Melanoma, and Blood cancer.

 

Lung Cancer:

Lung cancer is the leading cause of death worldwide. Immunotherapy has transformed the treatment landscape for patients with lung cancer by targeting tumor cells that are inaccessible to conventional therapies and immune system checkpoints. It binds to a protein on the surface of cancers (PD-L, CD80) and prevents it from stimulating an immune response against them. Immune checkpoint inhibitors have been found effective in non-small cell bronchial carcinomas as well as squamous cell lung carcinoma.

A phase III study showed a median overall survival time was significantly prolonged when immunotherapy was used alongside chemotherapy or radiotherapy therapy than chemo or radiation alone among metastatic NSCLC patients who had not received any previous treatments.

 

Colorectal Cancer:

Immune checkpoint inhibitors are also applied in the treatment of colorectal cancer. In this case, it is used for patients who have metastatic disease or those with previously treated locally advanced disease that has come back. The drug can be given as a single agent, but more commonly is combined with other drugs such as chemotherapy and radiation therapy.

Immunotherapy may improve survival rates by up to two years when used after surgery to remove the colon (colectomy) and/or rectum (proctectomy). This form of immunotherapy might be recommended if there are no signs that the tumor has spread outside of these areas during an examination called panendoscopy. Immunotherapy could help prevent tumors from coming back even though they had not been removed surgically.

 

Breast Cancer:

Immune checkpoint inhibitors are being used as a treatment option for cancer. In terms of breast cancer, they can be used in the following ways:

Injections (Ipilimumab) - Tumor vaccines and Gene Therapy – Immunotherapy associated with chemotherapy or targeted therapy

“Chemoimmunology” is an emerging field that aims to see how drugs can act on both sides of the tumor defense system at once—the immune response and DNA mutations.---There has been no definitive study yet about their efficacy against metastatic cancers. It's important to note these treatments should not replace standard therapies but rather work alongside them when appropriate medical management decisions have been made for each patient.

 

Prostate Cancer:

There are many uses for immune checkpoint inhibitors in prostate cancer. Immune checkpoint inhibitors have been shown to be effective on their own or combined with other medications, such as chemotherapy and radiation therapy before surgery, during radiotherapy after surgery if the tumor is too large for successful surgical removal without harming adjacent tissue structures, or following radical prostatectomy (removal of all visible parts of the tumor).

They may also work well to treat the metastatic disease which has spread throughout the body from a localized site but rarely used alone since it can result in an increase in resistance over time. In addition, they can prevent recurrence by slowing down the growth rates of residual cells that managed to survive treatment regimens.

 

Melanoma:

Immune checkpoint inhibitors work in melanoma by ensuring that the T-cells can detect and destroy cancer cells. They do this by blocking a protein called Programmed cell death Protein (PD-L) or cytotoxic T lymphocyte antigen (CTLA)-associated protein A(APA). Blocking PD-L or CTLA function has been shown to be more effective at inducing an immune response than other therapies, such as chemotherapy.

 

Blood Cancer:

Immune Checkpoint Inhibitors are used for the treatment of blood cancer. It can be combined with other treatments such as chemotherapy or radiotherapy to treat blood cancers like leukemia, lymphoma, and myelomas. CTLA-123 is a drug that inhibits CTLA-270 at the T cell level. It has been shown that this specific type of therapy may have promising results in patients with non-Hodgkin's B cell lymphoma (NHL).

 

On the basis of Region, the market is segmented into North America, Europe, Asia Pacific, and the Middle East. The European market is expected to be the largest market for Immune Checkpoint Inhibitors. The Asia Pacific market will grow at a high CAGR during 2021-2028, owing to an increase in investments and new product launches in China and India.

 


Up Market Research published a new report titled “Immune Checkpoint Inhibitors Market research report which is segmented by Types (PD-1/PD-L1, CTLA-4), By Applications (Lung Cancer, Colorectal Cancer, Breast Cancer, Prostate Cancer, Melanoma, Blood Cancer, Other), By Players/Companies Bristol Myer Squibb, AstraZeneca, Merck & Co., Roche / Genentech, Incyte Corporation, NewLink Genetics, ArGEN-X, Seattle Genetics, Pfizer, MacroGenics, Celldex Therapeutics, CureTech, Immutep, Innate Pharma, Sorrento Therapeutics, GlaxoSmithKline, GITR, Inc”. 

Report Scope

Report Attributes Report Details
Report Title Immune Checkpoint Inhibitors Market Research Report
By Type PD-1/PD-L1, CTLA-4
By Application Lung Cancer, Colorectal Cancer, Breast Cancer, Prostate Cancer, Melanoma, Blood Cancer, Other
By Companies Bristol Myer Squibb, AstraZeneca, Merck & Co., Roche / Genentech, Incyte Corporation, NewLink Genetics, ArGEN-X, Seattle Genetics, Pfizer, MacroGenics, Celldex Therapeutics, CureTech, Immutep, Innate Pharma, Sorrento Therapeutics, GlaxoSmithKline, GITR, Inc
Regions Covered North America, Europe, APAC, Latin America, MEA
Base Year 2020
Historical Year 2018 to 2019 (Data from 2010 can be provided as per availability)
Forecast Year 2028
Number of Pages 240
Number of Tables & Figures 168
Customization Available Yes, the report can be customized as per your need.
 

The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.


Global Immune Checkpoint Inhibitors Industry Outlook
 

Global Immune Checkpoint Inhibitors Market Report Segments:

The market is segmented by Type PD-1/PD-L1, CTLA-4 and By Application Lung Cancer, Colorectal Cancer, Breast Cancer, Prostate Cancer, Melanoma, Blood Cancer, Other.

 

Some of the companies that are profiled in this report are:

  1. Bristol Myer Squibb
  2. AstraZeneca
  3. Merck & Co.
  4. Roche / Genentech
  5. Incyte Corporation
  6. NewLink Genetics
  7. ArGEN-X
  8. Seattle Genetics
  9. Pfizer
  10. MacroGenics
  11. Celldex Therapeutics
  12. CureTech
  13. Immutep
  14. Innate Pharma
  15. Sorrento Therapeutics
  16. GlaxoSmithKline
  17. GITR, Inc
 

Immune Checkpoint Inhibitors Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.

 

Key Benefits for Industry Participants & Stakeholders:

  • Industry drivers, restraints, and opportunities covered in the study
  • Neutral perspective on the market performance
  • Recent industry trends and developments
  • Competitive landscape & strategies of key players
  • Potential & niche segments and regions exhibiting promising growth covered
  • Historical, current, and projected market size, in terms of value
  • In-depth analysis of the Immune Checkpoint Inhibitors Market
 

Overview of the regional outlook of the Immune Checkpoint Inhibitors Market:

Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.


Immune Checkpoint Inhibitors Market Overview
 

Highlights of The Immune Checkpoint Inhibitors Market Report:

  1. The market structure and projections for the coming years.
  2. Drivers, restraints, opportunities, and current trends of Immune Checkpoint Inhibitors Market.
  3. Historical data and forecast.
  4. Estimations for the forecast period 2028.
  5. Developments and trends in the market.
  6. By Type:

                1. PD-1/PD-L1

                2. CTLA-4

       7. By Application:

                1. Lung Cancer

                2. Colorectal Cancer

                3. Breast Cancer

                4. Prostate Cancer

                5. Melanoma

                6. Blood Cancer

                7. Other

  1. Market scenario by region, sub-region, and country.
  2. Market share of the market players, company profiles, product specifications, SWOT analysis, and competitive landscape.
  3. Analysis regarding upstream raw materials, downstream demand, and current market dynamics.
  4. Government Policies, Macro & Micro economic factors are also included in the report.
 

We have studied the Immune Checkpoint Inhibitors Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.

 

How you may use our products:

  • Correctly Positioning New Products
  • Market Entry Strategies
  • Business Expansion Strategies
  • Consumer Insights
  • Understanding Competition Scenario
  • Product & Brand Management
  • Channel & Customer Management
  • Identifying Appropriate Advertising Appeals

Immune Checkpoint Inhibitors Market Statistics
 

Reasons to Purchase the Immune Checkpoint Inhibitors Market Report:

  • The report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period
  • Segments and sub-segments include quantitative, qualitative, value (USD Million,) and volume (Units Million) data.
  • Regional, sub-regional, and country level data includes the demand and supply forces along with their influence on the market.
  • The competitive landscape comprises share of key players, new developments, and strategies in the last three years.
  • Comprehensive companies offering products, relevant financial information, recent developments, SWOT analysis, and strategies by these players.
Chapter 1 Executive Summary
Chapter 2 Assumptions and Acronyms Used
Chapter 3 Research Methodology
Chapter 4 Immune Checkpoint Inhibitors Market Overview
   4.1 Introduction 
      4.1.1 Market Taxonomy 
      4.1.2 Market Definition 
      4.1.3 Macro-Economic Factors Impacting the Market Growth 
   4.2 Immune Checkpoint Inhibitors Market Dynamics 
      4.2.1 Market Drivers 
      4.2.2 Market Restraints 
      4.2.3 Market Opportunity 
   4.3 Immune Checkpoint Inhibitors Market - Supply Chain Analysis 
      4.3.1 List of Key Suppliers 
      4.3.2 List of Key Distributors 
      4.3.3 List of Key Consumers 
   4.4 Key Forces Shaping the Immune Checkpoint Inhibitors Market 
      4.4.1 Bargaining Power of Suppliers 
      4.4.2 Bargaining Power of Buyers 
      4.4.3 Threat of Substitution 
      4.4.4 Threat of New Entrants 
      4.4.5 Competitive Rivalry 
   4.5 Global Immune Checkpoint Inhibitors Market Size & Forecast, 2018-2028 
      4.5.1 Immune Checkpoint Inhibitors Market Size and Y-o-Y Growth 
      4.5.2 Immune Checkpoint Inhibitors Market Absolute $ Opportunity 


Chapter 5 Global Immune Checkpoint Inhibitors Market Analysis and Forecast by Type
   5.1 Introduction
      5.1.1 Key Market Trends & Growth Opportunities by Type
      5.1.2 Basis Point Share (BPS) Analysis by Type
      5.1.3 Absolute $ Opportunity Assessment by Type
   5.2 Immune Checkpoint Inhibitors Market Size Forecast by Type
      5.2.1 PD-1/PD-L1
      5.2.2 CTLA-4
   5.3 Market Attractiveness Analysis by Type

Chapter 6 Global Immune Checkpoint Inhibitors Market Analysis and Forecast by Applications
   6.1 Introduction
      6.1.1 Key Market Trends & Growth Opportunities by Applications
      6.1.2 Basis Point Share (BPS) Analysis by Applications
      6.1.3 Absolute $ Opportunity Assessment by Applications
   6.2 Immune Checkpoint Inhibitors Market Size Forecast by Applications
      6.2.1 Lung Cancer
      6.2.2 Colorectal Cancer
      6.2.3 Breast Cancer
      6.2.4 Prostate Cancer
      6.2.5 Melanoma
      6.2.6 Blood Cancer
      6.2.7 Other
   6.3 Market Attractiveness Analysis by Applications

Chapter 7 Global Immune Checkpoint Inhibitors Market Analysis and Forecast by Region
   7.1 Introduction
      7.1.1 Key Market Trends & Growth Opportunities by Region
      7.1.2 Basis Point Share (BPS) Analysis by Region
      7.1.3 Absolute $ Opportunity Assessment by Region
   7.2 Immune Checkpoint Inhibitors Market Size Forecast by Region
      7.2.1 North America
      7.2.2 Europe
      7.2.3 Asia Pacific
      7.2.4 Latin America
      7.2.5 Middle East & Africa (MEA)
   7.3 Market Attractiveness Analysis by Region

Chapter 8 Coronavirus Disease (COVID-19) Impact 
   8.1 Introduction 
   8.2 Current & Future Impact Analysis 
   8.3 Economic Impact Analysis 
   8.4 Government Policies 
   8.5 Investment Scenario

Chapter 9 North America Immune Checkpoint Inhibitors Analysis and Forecast
   9.1 Introduction
   9.2 North America Immune Checkpoint Inhibitors Market Size Forecast by Country
      9.2.1 U.S.
      9.2.2 Canada
   9.3 Basis Point Share (BPS) Analysis by Country
   9.4 Absolute $ Opportunity Assessment by Country
   9.5 Market Attractiveness Analysis by Country
   9.6 North America Immune Checkpoint Inhibitors Market Size Forecast by Type
      9.6.1 PD-1/PD-L1
      9.6.2 CTLA-4
   9.7 Basis Point Share (BPS) Analysis by Type 
   9.8 Absolute $ Opportunity Assessment by Type 
   9.9 Market Attractiveness Analysis by Type
   9.10 North America Immune Checkpoint Inhibitors Market Size Forecast by Applications
      9.10.1 Lung Cancer
      9.10.2 Colorectal Cancer
      9.10.3 Breast Cancer
      9.10.4 Prostate Cancer
      9.10.5 Melanoma
      9.10.6 Blood Cancer
      9.10.7 Other
   9.11 Basis Point Share (BPS) Analysis by Applications 
   9.12 Absolute $ Opportunity Assessment by Applications 
   9.13 Market Attractiveness Analysis by Applications

Chapter 10 Europe Immune Checkpoint Inhibitors Analysis and Forecast
   10.1 Introduction
   10.2 Europe Immune Checkpoint Inhibitors Market Size Forecast by Country
      10.2.1 Germany
      10.2.2 France
      10.2.3 Italy
      10.2.4 U.K.
      10.2.5 Spain
      10.2.6 Russia
      10.2.7 Rest of Europe
   10.3 Basis Point Share (BPS) Analysis by Country
   10.4 Absolute $ Opportunity Assessment by Country
   10.5 Market Attractiveness Analysis by Country
   10.6 Europe Immune Checkpoint Inhibitors Market Size Forecast by Type
      10.6.1 PD-1/PD-L1
      10.6.2 CTLA-4
   10.7 Basis Point Share (BPS) Analysis by Type 
   10.8 Absolute $ Opportunity Assessment by Type 
   10.9 Market Attractiveness Analysis by Type
   10.10 Europe Immune Checkpoint Inhibitors Market Size Forecast by Applications
      10.10.1 Lung Cancer
      10.10.2 Colorectal Cancer
      10.10.3 Breast Cancer
      10.10.4 Prostate Cancer
      10.10.5 Melanoma
      10.10.6 Blood Cancer
      10.10.7 Other
   10.11 Basis Point Share (BPS) Analysis by Applications 
   10.12 Absolute $ Opportunity Assessment by Applications 
   10.13 Market Attractiveness Analysis by Applications

Chapter 11 Asia Pacific Immune Checkpoint Inhibitors Analysis and Forecast
   11.1 Introduction
   11.2 Asia Pacific Immune Checkpoint Inhibitors Market Size Forecast by Country
      11.2.1 China
      11.2.2 Japan
      11.2.3 South Korea
      11.2.4 India
      11.2.5 Australia
      11.2.6 South East Asia (SEA)
      11.2.7 Rest of Asia Pacific (APAC)
   11.3 Basis Point Share (BPS) Analysis by Country
   11.4 Absolute $ Opportunity Assessment by Country
   11.5 Market Attractiveness Analysis by Country
   11.6 Asia Pacific Immune Checkpoint Inhibitors Market Size Forecast by Type
      11.6.1 PD-1/PD-L1
      11.6.2 CTLA-4
   11.7 Basis Point Share (BPS) Analysis by Type 
   11.8 Absolute $ Opportunity Assessment by Type 
   11.9 Market Attractiveness Analysis by Type
   11.10 Asia Pacific Immune Checkpoint Inhibitors Market Size Forecast by Applications
      11.10.1 Lung Cancer
      11.10.2 Colorectal Cancer
      11.10.3 Breast Cancer
      11.10.4 Prostate Cancer
      11.10.5 Melanoma
      11.10.6 Blood Cancer
      11.10.7 Other
   11.11 Basis Point Share (BPS) Analysis by Applications 
   11.12 Absolute $ Opportunity Assessment by Applications 
   11.13 Market Attractiveness Analysis by Applications

Chapter 12 Latin America Immune Checkpoint Inhibitors Analysis and Forecast
   12.1 Introduction
   12.2 Latin America Immune Checkpoint Inhibitors Market Size Forecast by Country
      12.2.1 Brazil
      12.2.2 Mexico
      12.2.3 Rest of Latin America (LATAM)
   12.3 Basis Point Share (BPS) Analysis by Country
   12.4 Absolute $ Opportunity Assessment by Country
   12.5 Market Attractiveness Analysis by Country
   12.6 Latin America Immune Checkpoint Inhibitors Market Size Forecast by Type
      12.6.1 PD-1/PD-L1
      12.6.2 CTLA-4
   12.7 Basis Point Share (BPS) Analysis by Type 
   12.8 Absolute $ Opportunity Assessment by Type 
   12.9 Market Attractiveness Analysis by Type
   12.10 Latin America Immune Checkpoint Inhibitors Market Size Forecast by Applications
      12.10.1 Lung Cancer
      12.10.2 Colorectal Cancer
      12.10.3 Breast Cancer
      12.10.4 Prostate Cancer
      12.10.5 Melanoma
      12.10.6 Blood Cancer
      12.10.7 Other
   12.11 Basis Point Share (BPS) Analysis by Applications 
   12.12 Absolute $ Opportunity Assessment by Applications 
   12.13 Market Attractiveness Analysis by Applications

Chapter 13 Middle East & Africa (MEA) Immune Checkpoint Inhibitors Analysis and Forecast
   13.1 Introduction
   13.2 Middle East & Africa (MEA) Immune Checkpoint Inhibitors Market Size Forecast by Country
      13.2.1 Saudi Arabia
      13.2.2 South Africa
      13.2.3 UAE
      13.2.4 Rest of Middle East & Africa (MEA)
   13.3 Basis Point Share (BPS) Analysis by Country
   13.4 Absolute $ Opportunity Assessment by Country
   13.5 Market Attractiveness Analysis by Country
   13.6 Middle East & Africa (MEA) Immune Checkpoint Inhibitors Market Size Forecast by Type
      13.6.1 PD-1/PD-L1
      13.6.2 CTLA-4
   13.7 Basis Point Share (BPS) Analysis by Type 
   13.8 Absolute $ Opportunity Assessment by Type 
   13.9 Market Attractiveness Analysis by Type
   13.10 Middle East & Africa (MEA) Immune Checkpoint Inhibitors Market Size Forecast by Applications
      13.10.1 Lung Cancer
      13.10.2 Colorectal Cancer
      13.10.3 Breast Cancer
      13.10.4 Prostate Cancer
      13.10.5 Melanoma
      13.10.6 Blood Cancer
      13.10.7 Other
   13.11 Basis Point Share (BPS) Analysis by Applications 
   13.12 Absolute $ Opportunity Assessment by Applications 
   13.13 Market Attractiveness Analysis by Applications

Chapter 14 Competition Landscape 
   14.1 Immune Checkpoint Inhibitors Market: Competitive Dashboard
   14.2 Global Immune Checkpoint Inhibitors Market: Market Share Analysis, 2019
   14.3 Company Profiles (Details – Overview, Financials, Developments, Strategy) 
      14.3.1 Bristol Myer Squibb
      14.3.2 AstraZeneca
      14.3.3 Merck & Co.
      14.3.4 Roche / Genentech
      14.3.5 Incyte Corporation
      14.3.6 NewLink Genetics
      14.3.7 ArGEN-X
      14.3.8 Seattle Genetics
      14.3.9 Pfizer
      14.3.10 MacroGenics
      14.3.11 Celldex Therapeutics
      14.3.12 CureTech
      14.3.13 Immutep
      14.3.14 Innate Pharma
      14.3.15 Sorrento Therapeutics
      14.3.16 GlaxoSmithKline
      14.3.17 GITR, Inc
Segments Covered in the Report
The global Immune Checkpoint Inhibitors market has been segmented based on

By Types
  • PD-1/PD-L1
  • CTLA-4
By Applications
  • Lung Cancer
  • Colorectal Cancer
  • Breast Cancer
  • Prostate Cancer
  • Melanoma
  • Blood Cancer
  • Other
Regions
  • Asia Pacific
  • North America
  • Latin America
  • Europe
  • Middle East & Africa
Key Players
  • Bristol Myer Squibb
  • AstraZeneca
  • Merck & Co.
  • Roche / Genentech
  • Incyte Corporation
  • NewLink Genetics
  • ArGEN-X
  • Seattle Genetics
  • Pfizer
  • MacroGenics
  • Celldex Therapeutics
  • CureTech
  • Immutep
  • Innate Pharma
  • Sorrento Therapeutics
  • GlaxoSmithKline
  • GITR, Inc

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