Global antibody drug conjugates contract manufacturing market was valued at USD 7.2 billion in 2020. It is projected to grow at 12.3% compound annual growth rate (CAGR), between 2021 and 2028. Due to the rising incidence of cancer and the increased demand for biologic therapy as well as outsourcing operations and services to contract manufacturers, the market is expected to experience significant growth during the forecast period.
Many chemotherapy drugs have toxicities that can cause severe side effects. This can limit the effectiveness and dosage of the medication and place a substantial burden on patients. These side effects can be reduced by using an antibody drug conjugate. Antibody Drug Conjugates, also known as Antibody Drug Conjugates (ADC), allow the delivery of a particular medication dose to a site of interest. These are used most frequently in oncology, where a large dosage of medication is needed at the tumor site and not in adjacent tissue.
COVID-19 had a significant impact on healthcare, causing disruptions in the entire supply chain from raw materials to production and delivery. Major market players are involved in research and development, strategic alliances, collaborations and product launches to satisfy consumer needs for medicines, vaccinations, diagnostics and medical equipment.
CMOs can provide technical expertise in linker creation and conjugation, as well as solid platforms. An integrated CMO reduces the time it takes for an ADC to go to market. They can manage all stages of conjugation, scale up, commercial production, fill-finish, as well as scheduling and testing. ImmunoGen made the switch to outsource manufacturing of its ADCs in October 2018. This was due to the increased expertise provided by a CMO. The savings totalled $20 million.
The active pharmaceutical component industry (API), which was dominated historically by small-molecule drugs, is shifting rapidly towards biopharmaceuticals. The volume of production being outsourced to contract manufacturers is also increasing. Because of the complexity of manufacturing processes and concerns over intellectual property, biologics are made in-house. This has an impact on contract manufacturing businesses.
Myeloma dominated the market, accounting for 49.4% of the total revenue in 2020. Market growth is affected by antibody drug conjugates. This treatment, which delivers a powerful cytotoxic chemical directly into the myeloma cells, is a new type of treatment for myeloma sufferers.
Target is defined by the specificity of the monoclonal antibodies that are linked to the cytotoxic chemicals. This mechanism of action decreases cell damage by non-target cells and opens up therapeutic possibilities. ADCs are a viable option for myeloma treatment as they are 'off-the-shelf' therapies. It can be used in nearly all myeloma treatment centers and for a wide range of patients.
In 2020, the market for ADC contract manufacture was dominated by the cleavable linking segment. It accounted for 56.5% of the total revenue. This segment will likely continue to be dominant in the future. The advantages that cleavable links offer in certain situations to deliver the medication to the targeted cell is a major factor in the segment's growth. An ADC's success is determined by the characteristics of the linker between antibody and payload. Its effectiveness is attributed to its ability to distinguish between target-cell and circulatory conditions using cleavable links.
The segment with non-cleavable links is expected to see the fastest CAGR at 12.5% during the forecast period. ADCs that use non-cleavable linksers are more dependent on the biology of target cells. Plasma stability is higher for non-cleavable links than for cleavable, which can be beneficial in enhancing the therapeutic index.
Asia Pacific was the dominant market for ADC contract manufacturing and held the largest revenue share at 46.4% in 2020. Over the forecast period, the region will experience the fastest growth rate at 14.6%. Asia Pacific is responsible for 48.0% worldwide new cases of cancer, with China accounting almost half of these cases. Similar to the rest of the world, 55.0% are killed by cancer in Asia. In Asia, the incidence and death of cancer are expected to rise over the next 20 years.
Asia Pacific is the fastest growing pharmaceutical market in the world, offering huge potential for drug research and commercialization. This is why pharmaceutical regulations in the region are drawing a lot attention from pharmaceutical companies around the world. The growth of the regional market is due to the increased outsourcing of manufacturing operations to contract manufacturing companies.
To increase their market share, key players are pursuing strategic alliances that include mergers and acquisitions as well as collaborations and partnerships with market players. Cambrex Corporation announced in August 2019 that it had signed a formal agreement for Permira funds to purchase Cambrex Corporation. The transaction was valued at $2.4 million. Cambrex Corporation is unique in that it provides clinical trial materials for COVID-19 purposes to innovators. It also handles significant pressure when delivering goods during shortages of raw material or supply chain. The following are some of the most prominent players in antibody drug conjugates contract manufacture market:
Samsung Biologics
Lonza
Catalent
Siegfried
Piramal Pharma Solutions
Boehringer Ingelheim
Up Market Research published a new report titled “Antibody Drug Conjugates Contract Manufacturing Market research report which is segmented by Linker (Non-cleavable Linker, Cleavable Linker), by Condition (Breast Cancer, Myeloma, Lymphoma), By Players/Companies Piramal Pharma Solutions, Samsung Biologics, Boehringer Ingelheim, Lonza, Siegfried, Catalent”. As per the study the market is expected to grow at a CAGR of XX% in the forecast period.
Report Attributes | Report Details |
Report Title | Antibody Drug Conjugates Contract Manufacturing Market Research Report |
By Linker | Non-cleavable Linker, Cleavable Linker |
By Condition | Breast Cancer, Myeloma, Lymphoma |
By Companies | Piramal Pharma Solutions, Samsung Biologics, Boehringer Ingelheim, Lonza, Siegfried, Catalent |
Regions Covered | North America, Europe, APAC, Latin America, MEA |
Base Year | 2020 |
Historical Year | 2018 to 2019 (Data from 2010 can be provided as per availability) |
Forecast Year | 2028 |
Number of Pages | 248 |
Number of Tables & Figures | 174 |
Customization Available | Yes, the report can be customized as per your need. |
The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the industry. It provides an in-depth analysis of the market segments which include products, applications, and competitor analysis.
The market is segmented by Linker (Non-cleavable Linker, Cleavable Linker), by Condition (Breast Cancer, Myeloma, Lymphoma).
Antibody Drug Conjugates Contract Manufacturing Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.
Key Benefits for Industry Participants & Stakeholders:
Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa (MEA). North America region is further bifurcated into countries such as U.S., and Canada. The Europe region is further categorized into U.K., France, Germany, Italy, Spain, Russia, and Rest of Europe. Asia Pacific is further segmented into China, Japan, South Korea, India, Australia, South East Asia, and Rest of Asia Pacific. Latin America region is further segmented into Brazil, Mexico, and Rest of Latin America, and the MEA region is further divided into GCC, Turkey, South Africa, and Rest of MEA.
We have studied the Antibody Drug Conjugates Contract Manufacturing Market in 360 degrees via. both primary & secondary research methodologies. This helped us in building an understanding of the current market dynamics, supply-demand gap, pricing trends, product preferences, consumer patterns & so on. The findings were further validated through primary research with industry experts & opinion leaders across countries. The data is further compiled & validated through various market estimation & data validation methodologies. Further, we also have our in-house data forecasting model to predict market growth up to 2028.
How you may use our products:
Reasons to Purchase the Antibody Drug Conjugates Contract Manufacturing Market Report:
Some other reports from this category!